Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder
Major depressive disorder (MDD) is the most common psychiatric disorders. However, a biochemical marker has yet to be established for clinical purposes. It is proposed that lysophosphatidic acid (LPA, 1-acyl-2-sn-glycerol-3-phosphoate) plays some important roles in emotional regulation of experiment...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844018371962 |
| _version_ | 1818265262978236416 |
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| author | Leo Gotoh Misa Yamada Kotaro Hattori Daimei Sasayama Takamasa Noda Sumiko Yoshida Hiroshi Kunugi Mitsuhiko Yamada |
| author_facet | Leo Gotoh Misa Yamada Kotaro Hattori Daimei Sasayama Takamasa Noda Sumiko Yoshida Hiroshi Kunugi Mitsuhiko Yamada |
| author_sort | Leo Gotoh |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is the most common psychiatric disorders. However, a biochemical marker has yet to be established for clinical purposes. It is proposed that lysophosphatidic acid (LPA, 1-acyl-2-sn-glycerol-3-phosphoate) plays some important roles in emotional regulation of experimental animals. Therefore, in this study, we measured LPA levels using enzyme-linked immunosorbent assays of cerebrospinal fluid (CSF) and plasma samples from patients with MDD. The participants were 52 patients and 49 normal healthy controls for CSF study, and 47 patients and 44 controls for plasma study. We used the Japanese version of the GRID Hamilton Depression Rating Scale (17-item version) for the assessment of depressive symptoms. We found no associations between LPA levels (CSF or plasma) and either diagnosis or severity of MDD, or with psychotropic medication. In conclusion, our data suggest that LPA levels likely would not serve as a practical biomarker of MDD. |
| first_indexed | 2024-12-12T19:48:01Z |
| format | Article |
| id | doaj.art-1a7662eba5974ba0b1b56d9c0444a46e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T19:48:01Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-1a7662eba5974ba0b1b56d9c0444a46e2022-12-22T00:14:02ZengElsevierHeliyon2405-84402019-05-0155e01699Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorderLeo Gotoh0Misa Yamada1Kotaro Hattori2Daimei Sasayama3Takamasa Noda4Sumiko Yoshida5Hiroshi Kunugi6Mitsuhiko Yamada7Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, JapanDepartment of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan; Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, 187-8551, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, Japan; Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, JapanNational Center of Neurology and Psychiatry Hospital, Tokyo, 187-8551, JapanNational Center of Neurology and Psychiatry Hospital, Tokyo, 187-8551, Japan; Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, 187-8551, JapanDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187-8502, JapanDepartment of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, Japan; Corresponding author.Major depressive disorder (MDD) is the most common psychiatric disorders. However, a biochemical marker has yet to be established for clinical purposes. It is proposed that lysophosphatidic acid (LPA, 1-acyl-2-sn-glycerol-3-phosphoate) plays some important roles in emotional regulation of experimental animals. Therefore, in this study, we measured LPA levels using enzyme-linked immunosorbent assays of cerebrospinal fluid (CSF) and plasma samples from patients with MDD. The participants were 52 patients and 49 normal healthy controls for CSF study, and 47 patients and 44 controls for plasma study. We used the Japanese version of the GRID Hamilton Depression Rating Scale (17-item version) for the assessment of depressive symptoms. We found no associations between LPA levels (CSF or plasma) and either diagnosis or severity of MDD, or with psychotropic medication. In conclusion, our data suggest that LPA levels likely would not serve as a practical biomarker of MDD.http://www.sciencedirect.com/science/article/pii/S2405844018371962PsychiatryNeuroscience |
| spellingShingle | Leo Gotoh Misa Yamada Kotaro Hattori Daimei Sasayama Takamasa Noda Sumiko Yoshida Hiroshi Kunugi Mitsuhiko Yamada Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder Heliyon Psychiatry Neuroscience |
| title | Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| title_full | Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| title_fullStr | Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| title_full_unstemmed | Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| title_short | Lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| title_sort | lysophosphatidic acid levels in cerebrospinal fluid and plasma samples in patients with major depressive disorder |
| topic | Psychiatry Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2405844018371962 |
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