IL-10 Induced by mTNF Crosslinking-Mediated Reverse Signaling in a Whole Blood Assay Is Predictive of Response to TNFi Therapy in Rheumatoid Arthritis

IL-10 Induced by mTNF Crosslinking-Mediated Reverse Signaling in a Whole Blood Assay Is Predictive of Response to TNFi Therapy in Rheumatoid Arthritis

(1) Background: To date, the response of patients with rheumatoid arthritis (RA) to the various biologic DMARD available cannot be predicted due to a lack of reliable biomarkers. Based on our preliminary work on tmTNF reverse signaling, we developed a whole-blood assay measuring tmTNF crosslinking-i...

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Bibliographic Details
Main Authors: Marco Krasselt, Natalya Gruz, Matthias Pierer, Christoph Baerwald, Ulf Wagner
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Journal of Personalized Medicine
Subjects:
rheumatoid arthritis
bDMARD
TNF inhibitor
IL-10
prediction
reverse signalling
Online Access:https://www.mdpi.com/2075-4426/12/6/1003

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