Systematic investigations on the reduction of 4-aryl-4-oxoesters to 1-aryl-1,4-butanediols with methanolic sodium borohydride

Systematic investigations on the reduction of 4-aryl-4-oxoesters to 1-aryl-1,4-butanediols with methanolic sodium borohydride

4-Aryl-4-oxoesters undergo facile reduction of both the keto and the ester groups with methanolic NaBH4 at room temperature to yield the corresponding 1-aryl-1,4-butanediols whereas 4-alkyl-4-oxoesters furnish the corresponding 1,4-butanolides via selective reduction of the keto moiety. Results of a...

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Bibliographic Details
Main Authors: Subrata Kumar Chaudhuri, Manabendra Saha, Amit Saha, Sanjay Bhar
Format: Article
Language:English
Published: Beilstein-Institut 2010-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
diols
esters
lactones
reduction
Online Access:https://doi.org/10.3762/bjoc.6.94

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