Anti-E alloimmunization in a pregnancy with a low antibody titer
Red blood cell alloimmunization during pregnancy causes hemolytic disease of the fetus and newborn. While alloimmunization in pregnancy is treatable with anti-D antibodies, management with other antibodies has not been studied. A 32-year-old woman had anti-E antibodies detected during pregnancy, but...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.4267 |
| _version_ | 1811247807320817664 |
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| author | K. Nakanishi Y. Oishi T. Miyamoto E. Nakamura K. Murakami M. Ono A. Nozawa S. Kitamura K. Sengoku |
| author_facet | K. Nakanishi Y. Oishi T. Miyamoto E. Nakamura K. Murakami M. Ono A. Nozawa S. Kitamura K. Sengoku |
| author_sort | K. Nakanishi |
| collection | DOAJ |
| description | Red blood cell alloimmunization during pregnancy causes hemolytic disease of the fetus and newborn. While alloimmunization in pregnancy is treatable with anti-D antibodies, management with other antibodies has not been studied. A 32-year-old woman had anti-E antibodies detected during pregnancy, but the titer was < 1 : 2. Her newborn was admitted to hospital because direct Coombs tests were positive. Low titers of maternal anti-E antibodies were found in the newborn. We performed phototherapy and administered intravenous immunoglobulin because the newborn showed early jaundice and hyperkalemia, which suggested hemolytic disease. After being discharged at 6 days of age, the baby was readmitted to hospital at 9 days because of recurrent jaundice and underwent phototherapy. The baby was later discharged without recurrence of jaundice. Low anti-E antibody titers in pregnancy can cause alloimmunization, which can be treated successfully. The potential risk of hemolytic disease should be considered in cases with such low titers. |
| first_indexed | 2024-04-12T15:15:59Z |
| format | Article |
| id | doaj.art-1a80c879d62447429532b2f422beb1c6 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T15:15:59Z |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-1a80c879d62447429532b2f422beb1c62022-12-22T03:27:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147461461610.31083/j.ceog.2020.04.4267S0390-6663(20)00333-4Anti-E alloimmunization in a pregnancy with a low antibody titerK. Nakanishi0Y. Oishi1T. Miyamoto2E. Nakamura3K. Murakami4M. Ono5A. Nozawa6S. Kitamura7K. Sengoku8Department of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, JapanDepartment of Pediatrics, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Nayoro City General Hospital, Nayoro, JapanDepartment of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, JapanRed blood cell alloimmunization during pregnancy causes hemolytic disease of the fetus and newborn. While alloimmunization in pregnancy is treatable with anti-D antibodies, management with other antibodies has not been studied. A 32-year-old woman had anti-E antibodies detected during pregnancy, but the titer was < 1 : 2. Her newborn was admitted to hospital because direct Coombs tests were positive. Low titers of maternal anti-E antibodies were found in the newborn. We performed phototherapy and administered intravenous immunoglobulin because the newborn showed early jaundice and hyperkalemia, which suggested hemolytic disease. After being discharged at 6 days of age, the baby was readmitted to hospital at 9 days because of recurrent jaundice and underwent phototherapy. The baby was later discharged without recurrence of jaundice. Low anti-E antibody titers in pregnancy can cause alloimmunization, which can be treated successfully. The potential risk of hemolytic disease should be considered in cases with such low titers.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.4267alloimmunizationanti-e antibodyhemolytic disease of the fetus and newbornpregnancyrho(d) immunoglobulin. |
| spellingShingle | K. Nakanishi Y. Oishi T. Miyamoto E. Nakamura K. Murakami M. Ono A. Nozawa S. Kitamura K. Sengoku Anti-E alloimmunization in a pregnancy with a low antibody titer Clinical and Experimental Obstetrics & Gynecology alloimmunization anti-e antibody hemolytic disease of the fetus and newborn pregnancy rho(d) immunoglobulin. |
| title | Anti-E alloimmunization in a pregnancy with a low antibody titer |
| title_full | Anti-E alloimmunization in a pregnancy with a low antibody titer |
| title_fullStr | Anti-E alloimmunization in a pregnancy with a low antibody titer |
| title_full_unstemmed | Anti-E alloimmunization in a pregnancy with a low antibody titer |
| title_short | Anti-E alloimmunization in a pregnancy with a low antibody titer |
| title_sort | anti e alloimmunization in a pregnancy with a low antibody titer |
| topic | alloimmunization anti-e antibody hemolytic disease of the fetus and newborn pregnancy rho(d) immunoglobulin. |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.4267 |
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