Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represent...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/1021 |
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| author | Gonçalo Mesquita Natalia Prevarskaya Albrecht Schwab V’yacheslav Lehen’kyi |
| author_facet | Gonçalo Mesquita Natalia Prevarskaya Albrecht Schwab V’yacheslav Lehen’kyi |
| author_sort | Gonçalo Mesquita |
| collection | DOAJ |
| description | The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represented by nine sub-families that constitute the TRP channel superfamily. From the mid-2000s, several reports have shown the potential role of the TRP channels in cancers of multiple origin. The pancreatic cancer is one of the deadliest cancers worldwide. Its prevalence is predicted to rise further. Disappointingly, the treatments currently used are ineffective. There is an urgency to find new ways to counter this disease and one of the answers may lie in the ion channels belonging to the superfamily of TRP channels. In this review, we analyse the existing knowledge on the role of TRP channels in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The functions of these channels in other cancers are also considered. This might be of interest for an extrapolation to the pancreatic cancer in an attempt to identify potential therapeutic interventions. |
| first_indexed | 2024-03-10T11:56:41Z |
| format | Article |
| id | doaj.art-1a84c808c8df4987bdca28c1475365f0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:56:41Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1a84c808c8df4987bdca28c1475365f02023-11-21T17:13:19ZengMDPI AGCells2073-44092021-04-01105102110.3390/cells10051021Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and ProgressionGonçalo Mesquita0Natalia Prevarskaya1Albrecht Schwab2V’yacheslav Lehen’kyi3Laboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceInstitute of Physiology II, University Münster, 48149 Münster, GermanyLaboratory of Cell Physiology, INSERM U1003, Laboratory of Excellence Ion Channels Science and Therapeutics, Department of Biology, Faculty of Science and Technologies, University of Lille, 59650 Villeneuve d’Ascq, FranceThe transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of functions performed by these channels is represented by nine sub-families that constitute the TRP channel superfamily. From the mid-2000s, several reports have shown the potential role of the TRP channels in cancers of multiple origin. The pancreatic cancer is one of the deadliest cancers worldwide. Its prevalence is predicted to rise further. Disappointingly, the treatments currently used are ineffective. There is an urgency to find new ways to counter this disease and one of the answers may lie in the ion channels belonging to the superfamily of TRP channels. In this review, we analyse the existing knowledge on the role of TRP channels in the development and progression of pancreatic ductal adenocarcinoma (PDAC). The functions of these channels in other cancers are also considered. This might be of interest for an extrapolation to the pancreatic cancer in an attempt to identify potential therapeutic interventions.https://www.mdpi.com/2073-4409/10/5/1021ion channelsTRP channelspancreatic ductal adenocarcinoma |
| spellingShingle | Gonçalo Mesquita Natalia Prevarskaya Albrecht Schwab V’yacheslav Lehen’kyi Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression Cells ion channels TRP channels pancreatic ductal adenocarcinoma |
| title | Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression |
| title_full | Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression |
| title_fullStr | Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression |
| title_full_unstemmed | Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression |
| title_short | Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression |
| title_sort | role of the trp channels in pancreatic ductal adenocarcinoma development and progression |
| topic | ion channels TRP channels pancreatic ductal adenocarcinoma |
| url | https://www.mdpi.com/2073-4409/10/5/1021 |
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