Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis
The use of deoxyribonucleic acid (DNA) hybridization to detect disease-related gene expression is a valuable diagnostic tool. An ion-sensitive field-effect transistor (ISFET) with a graphene layer has been utilized for detecting DNA hybridization. Silicene is a two-dimensional silicon allotrope with...
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MDPI AG
2021-06-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/11/6/178 |
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| author | Md. Sazzadur Rahman Rokaia Laizu Naima Khatuna Jannatun Shetu Md. Mahabub Hossain M. Shamim Kaiser A. S. M. Sanwar Hosen Md. Abdul Latif Sarker Kelvin J. A. Ooi |
| author_facet | Md. Sazzadur Rahman Rokaia Laizu Naima Khatuna Jannatun Shetu Md. Mahabub Hossain M. Shamim Kaiser A. S. M. Sanwar Hosen Md. Abdul Latif Sarker Kelvin J. A. Ooi |
| author_sort | Md. Sazzadur Rahman |
| collection | DOAJ |
| description | The use of deoxyribonucleic acid (DNA) hybridization to detect disease-related gene expression is a valuable diagnostic tool. An ion-sensitive field-effect transistor (ISFET) with a graphene layer has been utilized for detecting DNA hybridization. Silicene is a two-dimensional silicon allotrope with structural properties similar to graphene. Thus, it has recently experienced intensive scientific research interest due to its unique electrical, mechanical, and sensing characteristics. In this paper, we proposed an ISFET structure with silicene and electrolyte layers for the label-free detection of DNA hybridization. When DNA hybridization occurs, it changes the ion concentration in the surface layer of the silicene and the pH level of the electrolyte solution. The process also changes the quantum capacitance of the silicene layer and the electrical properties of the ISFET device. The quantum capacitance and the corresponding resonant frequency readout of the silicene and graphene are compared. The performance evaluation found that the changes in quantum capacitance, resonant frequency, and tuning ratio indicate that the sensitivity of silicene is much more effective than graphene. |
| first_indexed | 2024-03-10T10:48:29Z |
| format | Article |
| id | doaj.art-1a852a3efa15460990c181766451ab11 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T10:48:29Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-1a852a3efa15460990c181766451ab112023-11-21T22:23:33ZengMDPI AGBiosensors2079-63742021-06-0111617810.3390/bios11060178Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation AnalysisMd. Sazzadur Rahman0Rokaia Laizu Naima1Khatuna Jannatun Shetu2Md. Mahabub Hossain3M. Shamim Kaiser4A. S. M. Sanwar Hosen5Md. Abdul Latif Sarker6Kelvin J. A. Ooi7Institute of Information Technology, Jahangirnagar University, Savar Dhaka-1342, BangladeshDepartment of Electronics and Communication Engineering, Hajee Mohammad Danesh Science & Technology University, Basherhat N508, BangladeshDepartment of Electronics and Communication Engineering, Hajee Mohammad Danesh Science & Technology University, Basherhat N508, BangladeshDepartment of Electronics and Communication Engineering, Hajee Mohammad Danesh Science & Technology University, Basherhat N508, BangladeshInstitute of Information Technology, Jahangirnagar University, Savar Dhaka-1342, BangladeshDivision of Computer Science and Engineering, Jeonbuk National University, Jeonju 54896, KoreaDepartment of Electronic Engineering, Hanyang University, Seoul 04763, KoreaDepartment of Physics, Xiamen University Malaysia, Sepang 43900, MalaysiaThe use of deoxyribonucleic acid (DNA) hybridization to detect disease-related gene expression is a valuable diagnostic tool. An ion-sensitive field-effect transistor (ISFET) with a graphene layer has been utilized for detecting DNA hybridization. Silicene is a two-dimensional silicon allotrope with structural properties similar to graphene. Thus, it has recently experienced intensive scientific research interest due to its unique electrical, mechanical, and sensing characteristics. In this paper, we proposed an ISFET structure with silicene and electrolyte layers for the label-free detection of DNA hybridization. When DNA hybridization occurs, it changes the ion concentration in the surface layer of the silicene and the pH level of the electrolyte solution. The process also changes the quantum capacitance of the silicene layer and the electrical properties of the ISFET device. The quantum capacitance and the corresponding resonant frequency readout of the silicene and graphene are compared. The performance evaluation found that the changes in quantum capacitance, resonant frequency, and tuning ratio indicate that the sensitivity of silicene is much more effective than graphene.https://www.mdpi.com/2079-6374/11/6/178biosensorpH detectionquantum capacitanceresonant frequencyISFETs |
| spellingShingle | Md. Sazzadur Rahman Rokaia Laizu Naima Khatuna Jannatun Shetu Md. Mahabub Hossain M. Shamim Kaiser A. S. M. Sanwar Hosen Md. Abdul Latif Sarker Kelvin J. A. Ooi Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis Biosensors biosensor pH detection quantum capacitance resonant frequency ISFETs |
| title | Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis |
| title_full | Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis |
| title_fullStr | Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis |
| title_full_unstemmed | Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis |
| title_short | Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization— A Simulation Analysis |
| title_sort | silicene quantum capacitance dependent frequency readout to a label free detection of dna hybridization a simulation analysis |
| topic | biosensor pH detection quantum capacitance resonant frequency ISFETs |
| url | https://www.mdpi.com/2079-6374/11/6/178 |
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