The dynamical mechanism of auto-inhibition of AMP-activated protein kinase.
We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Na...
| Những tác giả chính: | , |
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
Public Library of Science (PLoS)
2011-07-01
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| Loạt: | PLoS Computational Biology |
| Truy cập trực tuyến: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002082&type=printable |