Association of mitochondrial genetic variation with carotid atherosclerosis.
In human pathology, several diseases are associated with somatic mutations in the mitochondrial genome (mtDNA). Even though mitochondrial dysfunction leads to increased oxidative stress, the role of mitochondrial mutations in atherosclerosis has not received much attention so far. In this study we a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3706616?pdf=render |
| _version_ | 1818285820305473536 |
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| author | Igor A Sobenin Margarita A Sazonova Anton Y Postnov Jukka T Salonen Yuri V Bobryshev Alexander N Orekhov |
| author_facet | Igor A Sobenin Margarita A Sazonova Anton Y Postnov Jukka T Salonen Yuri V Bobryshev Alexander N Orekhov |
| author_sort | Igor A Sobenin |
| collection | DOAJ |
| description | In human pathology, several diseases are associated with somatic mutations in the mitochondrial genome (mtDNA). Even though mitochondrial dysfunction leads to increased oxidative stress, the role of mitochondrial mutations in atherosclerosis has not received much attention so far. In this study we analyzed the association of mitochondrial genetic variation with the severity of carotid atherosclerosis, as assessed by carotid intima-media thickness (cIMT) and the presence of coronary heart disease (CHD) in 190 subjects from Moscow, Russia, a population with high CHD occurrence. cIMT was measured by high-resolution B-mode ultrasonography and mtDNA heteroplasmies by a pyrosequencing-based method. We found that heteroplasmies for several mutations in the mtDNA in leukocytes, including C3256T, T3336C, G12315A, G13513A, G14459A, G14846A, and G15059A mutations, were significantly (p<0.001) associated with both the severity of carotid atherosclerosis and the presence of CHD. These findings indicate that somatic mitochondrial mutations have a role in the development of atherosclerosis. |
| first_indexed | 2024-12-13T01:14:46Z |
| format | Article |
| id | doaj.art-1a87917af3e14316893ef3385fe8c0b8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T01:14:46Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a87917af3e14316893ef3385fe8c0b82022-12-22T00:04:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6807010.1371/journal.pone.0068070Association of mitochondrial genetic variation with carotid atherosclerosis.Igor A SobeninMargarita A SazonovaAnton Y PostnovJukka T SalonenYuri V BobryshevAlexander N OrekhovIn human pathology, several diseases are associated with somatic mutations in the mitochondrial genome (mtDNA). Even though mitochondrial dysfunction leads to increased oxidative stress, the role of mitochondrial mutations in atherosclerosis has not received much attention so far. In this study we analyzed the association of mitochondrial genetic variation with the severity of carotid atherosclerosis, as assessed by carotid intima-media thickness (cIMT) and the presence of coronary heart disease (CHD) in 190 subjects from Moscow, Russia, a population with high CHD occurrence. cIMT was measured by high-resolution B-mode ultrasonography and mtDNA heteroplasmies by a pyrosequencing-based method. We found that heteroplasmies for several mutations in the mtDNA in leukocytes, including C3256T, T3336C, G12315A, G13513A, G14459A, G14846A, and G15059A mutations, were significantly (p<0.001) associated with both the severity of carotid atherosclerosis and the presence of CHD. These findings indicate that somatic mitochondrial mutations have a role in the development of atherosclerosis.http://europepmc.org/articles/PMC3706616?pdf=render |
| spellingShingle | Igor A Sobenin Margarita A Sazonova Anton Y Postnov Jukka T Salonen Yuri V Bobryshev Alexander N Orekhov Association of mitochondrial genetic variation with carotid atherosclerosis. PLoS ONE |
| title | Association of mitochondrial genetic variation with carotid atherosclerosis. |
| title_full | Association of mitochondrial genetic variation with carotid atherosclerosis. |
| title_fullStr | Association of mitochondrial genetic variation with carotid atherosclerosis. |
| title_full_unstemmed | Association of mitochondrial genetic variation with carotid atherosclerosis. |
| title_short | Association of mitochondrial genetic variation with carotid atherosclerosis. |
| title_sort | association of mitochondrial genetic variation with carotid atherosclerosis |
| url | http://europepmc.org/articles/PMC3706616?pdf=render |
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