Tacrolimus-induced Ascites after Liver Transplant
Massive post-transplantation ascites is a rare but serious condition following liver transplantation. Although, many etiologies are suggested as the cause of this complication, in some cases the definitive etiology remains unknown. Drug-induced post-transplantation ascites is one of the possible eti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-04-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/495 |
| _version_ | 1818991257152651264 |
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| author | M Hosseini M Aliakbarian K Akhavan-Rezayat O Shadkam S Milani |
| author_facet | M Hosseini M Aliakbarian K Akhavan-Rezayat O Shadkam S Milani |
| author_sort | M Hosseini |
| collection | DOAJ |
| description | Massive post-transplantation ascites is a rare but serious condition following liver transplantation. Although, many etiologies are suggested as the cause of this complication, in some cases the definitive etiology remains unknown. Drug-induced post-transplantation ascites is one of the possible etiologies. In this study we present a case of ascites caused by tacrolimus in the post-liver transplantation period. A 49-year-old man with hepatitis B virus cirrhosis underwent liver transplantation and received tacrolimus, mycophenolate and prednisolone, as the immunosuppressive regimen. Progressive ascites developed after 10 days, in spite of a normal liver function. Various studies, including liver biopsy, were performed but we could not find any etiology for this complication. The tacrolimus was switched to rapamune. Ascites was completely disappeared and up to the last follow-up visit, the patient remained asymptomatic for more than two years. We concluded that after ruling out other etiologies, tacrolimus as a rare cause of post-transplantation ascites should be taken into account. The treatment is discontinuation of the drug. |
| first_indexed | 2024-12-20T20:07:23Z |
| format | Article |
| id | doaj.art-1a8862cea95a468193eb4b34f946411f |
| institution | Directory Open Access Journal |
| issn | 2008-6482 2008-6490 |
| language | English |
| last_indexed | 2024-12-20T20:07:23Z |
| publishDate | 2018-04-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-1a8862cea95a468193eb4b34f946411f2022-12-21T19:27:54ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64822008-64902018-04-0192274Tacrolimus-induced Ascites after Liver TransplantM Hosseini0M Aliakbarian1K Akhavan-Rezayat2O Shadkam3S Milani4Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, and Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IranMassive post-transplantation ascites is a rare but serious condition following liver transplantation. Although, many etiologies are suggested as the cause of this complication, in some cases the definitive etiology remains unknown. Drug-induced post-transplantation ascites is one of the possible etiologies. In this study we present a case of ascites caused by tacrolimus in the post-liver transplantation period. A 49-year-old man with hepatitis B virus cirrhosis underwent liver transplantation and received tacrolimus, mycophenolate and prednisolone, as the immunosuppressive regimen. Progressive ascites developed after 10 days, in spite of a normal liver function. Various studies, including liver biopsy, were performed but we could not find any etiology for this complication. The tacrolimus was switched to rapamune. Ascites was completely disappeared and up to the last follow-up visit, the patient remained asymptomatic for more than two years. We concluded that after ruling out other etiologies, tacrolimus as a rare cause of post-transplantation ascites should be taken into account. The treatment is discontinuation of the drug.http://www.ijotm.com/ojs/index.php/IJOTM/article/view/495AscitesTacrolimusLiver transplantationImmunosuppressive agents |
| spellingShingle | M Hosseini M Aliakbarian K Akhavan-Rezayat O Shadkam S Milani Tacrolimus-induced Ascites after Liver Transplant International Journal of Organ Transplantation Medicine Ascites Tacrolimus Liver transplantation Immunosuppressive agents |
| title | Tacrolimus-induced Ascites after Liver Transplant |
| title_full | Tacrolimus-induced Ascites after Liver Transplant |
| title_fullStr | Tacrolimus-induced Ascites after Liver Transplant |
| title_full_unstemmed | Tacrolimus-induced Ascites after Liver Transplant |
| title_short | Tacrolimus-induced Ascites after Liver Transplant |
| title_sort | tacrolimus induced ascites after liver transplant |
| topic | Ascites Tacrolimus Liver transplantation Immunosuppressive agents |
| url | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/495 |
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