The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis
Abstract The loss of skeletal muscle mass and function is defined as sarcopenia, which might develop in elderly patients with cancers. It has been indicated as a potential negative factor in the survival of patients with malignant tumours. The aim of this systematic review and meta‐analysis was to e...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13126 |
| _version_ | 1797805537657618432 |
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| author | Pinhao Fang Jianfeng Zhou Xin Xiao Yushang Yang Siyuan Luan Zhiwen Liang Xiaokun Li Hanlu Zhang Qixin Shang Xiaoxi Zeng Yong Yuan |
| author_facet | Pinhao Fang Jianfeng Zhou Xin Xiao Yushang Yang Siyuan Luan Zhiwen Liang Xiaokun Li Hanlu Zhang Qixin Shang Xiaoxi Zeng Yong Yuan |
| author_sort | Pinhao Fang |
| collection | DOAJ |
| description | Abstract The loss of skeletal muscle mass and function is defined as sarcopenia, which might develop in elderly patients with cancers. It has been indicated as a potential negative factor in the survival of patients with malignant tumours. The aim of this systematic review and meta‐analysis was to evaluate the associations between sarcopenia and survival outcomes or postoperative complications in patients with oesophageal cancer (EC). Web of Science, Embase, Medline, and Cochrane Library databases were searched until 10 May 2022, using keywords: sarcopenia, oesophageal cancer, and prognosis. Studies investigating the prognostic value of sarcopenia on EC survival were included. Forest plots and summary effect models were used to show the result of this meta‐analysis. The quality of included studies was evaluated with the Newcastle‐Ottawa Scale (NOS). A total of 1436 studies were identified from the initial search of four databases, and 41 studies were included for the final quantitative analysis. This meta‐analysis revealed a significant association between sarcopenia and overall survival (OS) [hazard ratios (HR):1.68, 95% confidence interval (CI):1.54–1.83, P = 0.004, I2 = 41.7%] or disease‐free survival (DFS) 1.97 (HR: 1.97, 95% CI: 1.44–2.69, P = 0.007, I2 = 61.9%) of EC patients. Subgroup analysis showed that sarcopenia remained a consistent negative predictor of survival when stratified by different treatment methods, populations, or sarcopenia measurements. Sarcopenia was also a risk factor for postoperative complications with a pooled odds ratio of 1.47 (95% CI: 1.21–1.77, P = 0.094, I2 = 32.7%). The NOS scores of all included studies were ≥6, and the quality of the evidence was relatively high. The results from the study suggested that sarcopenia was significantly associated with both survival outcomes and postoperative complications in EC patients. Sarcopenia should be appropriately diagnosed and treated for improving short‐term and long‐term outcomes of patients with EC. |
| first_indexed | 2024-03-13T05:53:33Z |
| format | Article |
| id | doaj.art-1a88ce9a40bb4a85b21f796b31ddd0e3 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-03-13T05:53:33Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-1a88ce9a40bb4a85b21f796b31ddd0e32023-06-13T07:50:49ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092023-02-0114131610.1002/jcsm.13126The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysisPinhao Fang0Jianfeng Zhou1Xin Xiao2Yushang Yang3Siyuan Luan4Zhiwen Liang5Xiaokun Li6Hanlu Zhang7Qixin Shang8Xiaoxi Zeng9Yong Yuan10Department of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaWest China Biomedical Big Data Center, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaDepartment of Thoracic Surgery, Med+X Center for Informatics, West China Hospital Sichuan University Chengdu ChinaAbstract The loss of skeletal muscle mass and function is defined as sarcopenia, which might develop in elderly patients with cancers. It has been indicated as a potential negative factor in the survival of patients with malignant tumours. The aim of this systematic review and meta‐analysis was to evaluate the associations between sarcopenia and survival outcomes or postoperative complications in patients with oesophageal cancer (EC). Web of Science, Embase, Medline, and Cochrane Library databases were searched until 10 May 2022, using keywords: sarcopenia, oesophageal cancer, and prognosis. Studies investigating the prognostic value of sarcopenia on EC survival were included. Forest plots and summary effect models were used to show the result of this meta‐analysis. The quality of included studies was evaluated with the Newcastle‐Ottawa Scale (NOS). A total of 1436 studies were identified from the initial search of four databases, and 41 studies were included for the final quantitative analysis. This meta‐analysis revealed a significant association between sarcopenia and overall survival (OS) [hazard ratios (HR):1.68, 95% confidence interval (CI):1.54–1.83, P = 0.004, I2 = 41.7%] or disease‐free survival (DFS) 1.97 (HR: 1.97, 95% CI: 1.44–2.69, P = 0.007, I2 = 61.9%) of EC patients. Subgroup analysis showed that sarcopenia remained a consistent negative predictor of survival when stratified by different treatment methods, populations, or sarcopenia measurements. Sarcopenia was also a risk factor for postoperative complications with a pooled odds ratio of 1.47 (95% CI: 1.21–1.77, P = 0.094, I2 = 32.7%). The NOS scores of all included studies were ≥6, and the quality of the evidence was relatively high. The results from the study suggested that sarcopenia was significantly associated with both survival outcomes and postoperative complications in EC patients. Sarcopenia should be appropriately diagnosed and treated for improving short‐term and long‐term outcomes of patients with EC.https://doi.org/10.1002/jcsm.13126SarcopeniaOesophageal cancerSkeletal muscle indexPrognosisMeta‐analysis |
| spellingShingle | Pinhao Fang Jianfeng Zhou Xin Xiao Yushang Yang Siyuan Luan Zhiwen Liang Xiaokun Li Hanlu Zhang Qixin Shang Xiaoxi Zeng Yong Yuan The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis Journal of Cachexia, Sarcopenia and Muscle Sarcopenia Oesophageal cancer Skeletal muscle index Prognosis Meta‐analysis |
| title | The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis |
| title_full | The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis |
| title_fullStr | The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis |
| title_full_unstemmed | The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis |
| title_short | The prognostic value of sarcopenia in oesophageal cancer: A systematic review and meta‐analysis |
| title_sort | prognostic value of sarcopenia in oesophageal cancer a systematic review and meta analysis |
| topic | Sarcopenia Oesophageal cancer Skeletal muscle index Prognosis Meta‐analysis |
| url | https://doi.org/10.1002/jcsm.13126 |
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