Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications
Liver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cance...
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| Materialtyp: | Artikel |
| Språk: | English |
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Frontiers Media S.A.
2024-03-01
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| Serie: | Frontiers in Pharmacology |
| Ämnen: | |
| Länkar: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1376005/full |
| _version_ | 1827319171691577344 |
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| author | Jindu Zhao Guo-Ying Li Xian-Ying Lu Li-Ran Zhu Qun Gao |
| author_facet | Jindu Zhao Guo-Ying Li Xian-Ying Lu Li-Ran Zhu Qun Gao |
| author_sort | Jindu Zhao |
| collection | DOAJ |
| description | Liver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cancer progression remain largely elusive. N6-methyladenosine (m6A) modification, as the most prevalent and abundant internal RNA modification in eukaryotic RNAs, plays an essential role in regulating RNA metabolism including RNA splicing, stability, translation, degradation. To date, there is mounting evidence showing that m6A dysregulation is closely associated with the onset and development of many tumors including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and hepatoblastoma (HB). In this review, we summarize the last research progress regarding the functions of m6A-related regulators in liver cancer and its underlying mechanisms. Additionally, we also discuss the therapeutic applications of m6A-based inhibitors in liver cancer treatment. |
| first_indexed | 2024-04-25T00:15:30Z |
| format | Article |
| id | doaj.art-1a8a4003e2894d9f8035de6427b72e8f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-25T00:15:30Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-1a8a4003e2894d9f8035de6427b72e8f2024-03-13T04:47:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-03-011510.3389/fphar.2024.13760051376005Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implicationsJindu Zhao0Guo-Ying Li1Xian-Ying Lu2Li-Ran Zhu3Qun Gao4Department of Oncology Surgery, Anhui Medical University Children’s Medical Center, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaCollege of Integrative Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, ChinaDepartment of Oncology Surgery, Anhui Medical University Children’s Medical Center, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaAnhui Institute of Pediatric Research, Anhui Medical University Children’s Medical Center, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaDepartment of Oncology Surgery, Anhui Medical University Children’s Medical Center, Anhui Provincial Children’s Hospital, Hefei, Anhui, ChinaLiver cancer remains as the third leading cause of cancer-related death globally as of 2020. Despite the significant progress made in the field of liver cancer treatment, there is still a lack of effective therapies in patients with advanced cancer and the molecular mechanisms underlying liver cancer progression remain largely elusive. N6-methyladenosine (m6A) modification, as the most prevalent and abundant internal RNA modification in eukaryotic RNAs, plays an essential role in regulating RNA metabolism including RNA splicing, stability, translation, degradation. To date, there is mounting evidence showing that m6A dysregulation is closely associated with the onset and development of many tumors including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and hepatoblastoma (HB). In this review, we summarize the last research progress regarding the functions of m6A-related regulators in liver cancer and its underlying mechanisms. Additionally, we also discuss the therapeutic applications of m6A-based inhibitors in liver cancer treatment.https://www.frontiersin.org/articles/10.3389/fphar.2024.1376005/fullliver cancerN6-methyladenosine (m6A) modificationHCCICCHB |
| spellingShingle | Jindu Zhao Guo-Ying Li Xian-Ying Lu Li-Ran Zhu Qun Gao Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications Frontiers in Pharmacology liver cancer N6-methyladenosine (m6A) modification HCC ICC HB |
| title | Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications |
| title_full | Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications |
| title_fullStr | Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications |
| title_full_unstemmed | Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications |
| title_short | Landscape of m6A RNA methylation regulators in liver cancer and its therapeutic implications |
| title_sort | landscape of m6a rna methylation regulators in liver cancer and its therapeutic implications |
| topic | liver cancer N6-methyladenosine (m6A) modification HCC ICC HB |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1376005/full |
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