Influence of KCNJ11 gene polymorphism in T2DM of south Indian population
Type-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 poly...
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IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Elite |
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| Online Access: | https://www.imrpress.com/journal/FBE/12/2/10.2741/E867 |
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| author | Rajagopalan Aswathi Dhasaiya Viji Prathap Seelan Pricilla Charmine Rehman Syed Rasheed Akram Husain Sahul Hameed Noorul Ameen Shiek SSJ Ahmed Veerabathiran Ramakrishnan |
| author_facet | Rajagopalan Aswathi Dhasaiya Viji Prathap Seelan Pricilla Charmine Rehman Syed Rasheed Akram Husain Sahul Hameed Noorul Ameen Shiek SSJ Ahmed Veerabathiran Ramakrishnan |
| author_sort | Rajagopalan Aswathi |
| collection | DOAJ |
| description | Type-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 polymorphism towards an increased risk of T2DM compared to controls with an odds ratio (OR) of 2.52, confidence interval (CI) (0.96-6.64) and p-value 0.046. The functional influence of rs5219 was tested which showed a significant correlation with HbA1c and serum uric acid levels. Although our results confirm rs5219 is a potential contributor to T2DM, several inconclusive results were noticed across the literature. Hence, the meta-analysis was performed by combining the results of case-control study with previous literature to confirm the rs5219 association with T2DM across various populations. Our meta-analysis revealed a significant risk association of rs5219 in T2DM under five genetic models. In summary, our analysis suggests, rs5219 polymorphism plays a significant role in T2DM susceptibility. Further, studies need to be conducted to determine the influence of rs5219 on the other characteristics of T2DM. |
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| id | doaj.art-1a8b014ce34148209b289f34d4ff10a9 |
| institution | Directory Open Access Journal |
| issn | 1945-0494 |
| language | English |
| last_indexed | 2024-04-14T00:45:47Z |
| publishDate | 2020-03-01 |
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| series | Frontiers in Bioscience-Elite |
| spelling | doaj.art-1a8b014ce34148209b289f34d4ff10a92022-12-22T02:22:01ZengIMR PressFrontiers in Bioscience-Elite1945-04942020-03-0112219922210.2741/E867S1945-0494(20)00013-2Influence of KCNJ11 gene polymorphism in T2DM of south Indian populationRajagopalan Aswathi0Dhasaiya Viji1Prathap Seelan Pricilla Charmine2Rehman Syed Rasheed Akram Husain3Sahul Hameed Noorul Ameen4Shiek SSJ Ahmed5Veerabathiran Ramakrishnan6Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaGenetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaGenetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaGenetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaDepartment of General Medicine, Chettinad Hospital and Research Institute, Chettinad Health City, Kelambakkam 603103, Tamil Nadu, IndiaDrug Discovery Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaGenetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, IndiaType-2 Diabetes mellitus (T2DM) is a complex metabolic disease. A case-control study was conducted with 218 T2DM and 214 controls to evaluate the T2DM risk of rs5219 polymorphism in the south Indian population. The analysis of allelic and genotype data showed a significant association of rs5219 polymorphism towards an increased risk of T2DM compared to controls with an odds ratio (OR) of 2.52, confidence interval (CI) (0.96-6.64) and p-value 0.046. The functional influence of rs5219 was tested which showed a significant correlation with HbA1c and serum uric acid levels. Although our results confirm rs5219 is a potential contributor to T2DM, several inconclusive results were noticed across the literature. Hence, the meta-analysis was performed by combining the results of case-control study with previous literature to confirm the rs5219 association with T2DM across various populations. Our meta-analysis revealed a significant risk association of rs5219 in T2DM under five genetic models. In summary, our analysis suggests, rs5219 polymorphism plays a significant role in T2DM susceptibility. Further, studies need to be conducted to determine the influence of rs5219 on the other characteristics of T2DM.https://www.imrpress.com/journal/FBE/12/2/10.2741/E867diabetic mellituskcnj11polymorphismassociatione23 |
| spellingShingle | Rajagopalan Aswathi Dhasaiya Viji Prathap Seelan Pricilla Charmine Rehman Syed Rasheed Akram Husain Sahul Hameed Noorul Ameen Shiek SSJ Ahmed Veerabathiran Ramakrishnan Influence of KCNJ11 gene polymorphism in T2DM of south Indian population Frontiers in Bioscience-Elite diabetic mellitus kcnj11 polymorphism association e23 |
| title | Influence of KCNJ11 gene polymorphism in T2DM of south Indian population |
| title_full | Influence of KCNJ11 gene polymorphism in T2DM of south Indian population |
| title_fullStr | Influence of KCNJ11 gene polymorphism in T2DM of south Indian population |
| title_full_unstemmed | Influence of KCNJ11 gene polymorphism in T2DM of south Indian population |
| title_short | Influence of KCNJ11 gene polymorphism in T2DM of south Indian population |
| title_sort | influence of kcnj11 gene polymorphism in t2dm of south indian population |
| topic | diabetic mellitus kcnj11 polymorphism association e23 |
| url | https://www.imrpress.com/journal/FBE/12/2/10.2741/E867 |
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