Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney
Objective: Mercuric chloride (Merc; HgCl2) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalco...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2023-07-01
|
| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | https://ajp.mums.ac.ir/article_21872_5f2337619a2b3b1452cad507a8dc52fd.pdf |
| _version_ | 1797741039734226944 |
|---|---|
| author | Ali Ghanbari Cyrus Jalili Amir Abdolmaleki Mohsen Zhaleh Armin Zarinkhat Nasim Akhshi |
| author_facet | Ali Ghanbari Cyrus Jalili Amir Abdolmaleki Mohsen Zhaleh Armin Zarinkhat Nasim Akhshi |
| author_sort | Ali Ghanbari |
| collection | DOAJ |
| description | Objective: Mercuric chloride (Merc; HgCl2) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalcoholic extract effects on kidney toxicity induced by Merc.Materials and Methods: Forty-eight male rats were divided into eight groups: the control group: received saline; the Merc group: received 0.5 ml/day of 0.5 ppm aqueous Merc; FV1, 2, and 3 groups: received 50, 100, 150 mg/kg FV, respectively; and Merc + FV1, 2, and 3 groups: received Merc and FV at three doses. The administration period was 14-days. Subsequently, kidneys and sera were cumulated from each group for the analysis. Samples were analyzed via hematoxylin-eosin staining and biochemical tests.Results: The rats that received Merc displayed significant decrement in the kidney index, the diameter of renal corpuscles, total antioxidant capacity levels, superoxide dismutase activity (all, p<0.01), and 150 mg/kg FV mitigated these outcomes (all, p<0.05). Urea, creatinine, nitric oxide, and the level of apoptosis revealed a significant increment in the kidney of the rats that received Merc (all, p<0.01), and 150 mg/kg FV decreased these results. Furthermore, FV ameliorated histological changes induced by Merc (all, p<0.05). Conclusion: The FV hydroalcoholic extract protects the kidneys against Merc-induced nephrotoxicity. Antioxidant and anti-apoptotic FV hydroalcoholic extract properties were involved in this healing effect. |
| first_indexed | 2024-03-12T14:21:08Z |
| format | Article |
| id | doaj.art-1a8c5a457a1c47c5bcdc25aed175f01a |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-03-12T14:21:08Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-1a8c5a457a1c47c5bcdc25aed175f01a2023-08-19T03:20:24ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-07-0113444245310.22038/ajp.2023.2187221872Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidneyAli Ghanbari0Cyrus Jalili1Amir Abdolmaleki2Mohsen Zhaleh3Armin Zarinkhat4Nasim Akhshi5Department of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, IranDepartment of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, IranStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, IranStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Anatomical Sciences, Kermanshah University of Medical Sciences, School of Medicine, Kermanshah, IranObjective: Mercuric chloride (Merc; HgCl2) is toxic to humans and animals and contributes to environmental pollution, which usually results in nerve and systemic harm to different organs. Falcaria vulgaris (FV) is a medicinal plant rich in antioxidants. This research aimed to assess the FV hydroalcoholic extract effects on kidney toxicity induced by Merc.Materials and Methods: Forty-eight male rats were divided into eight groups: the control group: received saline; the Merc group: received 0.5 ml/day of 0.5 ppm aqueous Merc; FV1, 2, and 3 groups: received 50, 100, 150 mg/kg FV, respectively; and Merc + FV1, 2, and 3 groups: received Merc and FV at three doses. The administration period was 14-days. Subsequently, kidneys and sera were cumulated from each group for the analysis. Samples were analyzed via hematoxylin-eosin staining and biochemical tests.Results: The rats that received Merc displayed significant decrement in the kidney index, the diameter of renal corpuscles, total antioxidant capacity levels, superoxide dismutase activity (all, p<0.01), and 150 mg/kg FV mitigated these outcomes (all, p<0.05). Urea, creatinine, nitric oxide, and the level of apoptosis revealed a significant increment in the kidney of the rats that received Merc (all, p<0.01), and 150 mg/kg FV decreased these results. Furthermore, FV ameliorated histological changes induced by Merc (all, p<0.05). Conclusion: The FV hydroalcoholic extract protects the kidneys against Merc-induced nephrotoxicity. Antioxidant and anti-apoptotic FV hydroalcoholic extract properties were involved in this healing effect.https://ajp.mums.ac.ir/article_21872_5f2337619a2b3b1452cad507a8dc52fd.pdfantioxidantskidneymercuric chloridenitric oxideoxidative stress |
| spellingShingle | Ali Ghanbari Cyrus Jalili Amir Abdolmaleki Mohsen Zhaleh Armin Zarinkhat Nasim Akhshi Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney Avicenna Journal of Phytomedicine antioxidants kidney mercuric chloride nitric oxide oxidative stress |
| title | Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| title_full | Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| title_fullStr | Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| title_full_unstemmed | Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| title_short | Falcaria vulgaris L. hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| title_sort | falcaria vulgaris l hydroalcoholic extract protects against harmful effects of mercuric chloride on the rat kidney |
| topic | antioxidants kidney mercuric chloride nitric oxide oxidative stress |
| url | https://ajp.mums.ac.ir/article_21872_5f2337619a2b3b1452cad507a8dc52fd.pdf |
| work_keys_str_mv | AT alighanbari falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney AT cyrusjalili falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney AT amirabdolmaleki falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney AT mohsenzhaleh falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney AT arminzarinkhat falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney AT nasimakhshi falcariavulgarislhydroalcoholicextractprotectsagainstharmfuleffectsofmercuricchlorideontheratkidney |