Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil
Abstract INTRODUCTION We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective. METHODS A Markov model was derived using a cohort of stage F0-F2 patients treated...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2020-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100651&tlng=en |
| _version_ | 1811245406307221504 |
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| author | Vinicius Lins Ferreira Leticia Paula Leonart Maria Lucia Alves Pedroso Roberto Pontarolo |
| author_facet | Vinicius Lins Ferreira Leticia Paula Leonart Maria Lucia Alves Pedroso Roberto Pontarolo |
| author_sort | Vinicius Lins Ferreira |
| collection | DOAJ |
| description | Abstract INTRODUCTION We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective. METHODS A Markov model was derived using a cohort of stage F0-F2 patients treated as recommended by the Brazilian national guidelines. RESULTS: Glecaprevir plus pibrentasvir was superior to all other treatments, followed by sofosbuvir plus velpatasvir. Sofosbuvir plus daclatasvir was identified as the least cost-effective option. CONCLUSIONS: The above findings were confirmed via probabilistic sensitivity analysis and the tested scenarios. |
| first_indexed | 2024-04-12T14:39:37Z |
| format | Article |
| id | doaj.art-1a8cdbed73894bb282a90ee5a3b422ed |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-12T14:39:37Z |
| publishDate | 2020-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-1a8cdbed73894bb282a90ee5a3b422ed2022-12-22T03:28:55ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492020-06-015310.1590/0037-8682-0594-2019Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in BrazilVinicius Lins FerreiraLeticia Paula LeonartMaria Lucia Alves PedrosoRoberto Pontarolohttps://orcid.org/0000-0002-7049-4363Abstract INTRODUCTION We conducted a cost-utility analysis of available interferon-free treatments for patients with early-stage genotype 1 chronic hepatitis C based on a Brazilian public health system perspective. METHODS A Markov model was derived using a cohort of stage F0-F2 patients treated as recommended by the Brazilian national guidelines. RESULTS: Glecaprevir plus pibrentasvir was superior to all other treatments, followed by sofosbuvir plus velpatasvir. Sofosbuvir plus daclatasvir was identified as the least cost-effective option. CONCLUSIONS: The above findings were confirmed via probabilistic sensitivity analysis and the tested scenarios.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100651&tlng=enHepatitis CCost-effectiveness analysisTreatmentBrazil |
| spellingShingle | Vinicius Lins Ferreira Leticia Paula Leonart Maria Lucia Alves Pedroso Roberto Pontarolo Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil Revista da Sociedade Brasileira de Medicina Tropical Hepatitis C Cost-effectiveness analysis Treatment Brazil |
| title | Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil |
| title_full | Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil |
| title_fullStr | Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil |
| title_full_unstemmed | Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil |
| title_short | Cost-utility analysis of interferon-free treatments for patients with early-stage genotype 1 hepatitis C virus in Brazil |
| title_sort | cost utility analysis of interferon free treatments for patients with early stage genotype 1 hepatitis c virus in brazil |
| topic | Hepatitis C Cost-effectiveness analysis Treatment Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100651&tlng=en |
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