Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats
Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study u...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2017.1282554 |
| _version_ | 1819099673705578496 |
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| author | Ahmed Alalaiwe Georgia Roberts Paul Carpinone John Munson Stephen Roberts |
| author_facet | Ahmed Alalaiwe Georgia Roberts Paul Carpinone John Munson Stephen Roberts |
| author_sort | Ahmed Alalaiwe |
| collection | DOAJ |
| description | Metallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study used the classical method of comparing blood concentration area under the curve (AUC) following intravenous and oral doses to determine the oral bioavailability of 1, 2 and 5 kDa PEG-coated 5 nm gold nanoparticles (AuNPs). Male rats were given a single intravenous dose (0.8 mg/kg) or oral (gavage) dose (8 mg/kg) of a PEG-coated AuNP, and the concentration of gold was measured in blood over time and in tissues (liver, spleen and kidney) at sacrifice. Blood concentrations following oral administration were inversely related to PEG size, and the AUC in blood was significantly greater for the 1 kDa PEG-coated AuNPs than particles coated with 2 or 5 kDa PEG. However, bioavailabilities of all of the particles were very low (< 0.1%). Concentrations in liver, spleen and kidney were similar after the intravenous doses, but kidney showed the highest concentrations after an oral dose. In addition to providing information on the bioavailability of AuNPs coated with PEG in the 1–5 kDa range, this study demonstrates the utility of applying the blood AUC approach to assess the quantitative oral bioavailability of metallic nanoparticles. |
| first_indexed | 2024-12-22T00:50:37Z |
| format | Article |
| id | doaj.art-1a8d13a7d56445d7921782ab99a2aa3c |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-22T00:50:37Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-1a8d13a7d56445d7921782ab99a2aa3c2022-12-21T18:44:27ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642017-01-0124159159810.1080/10717544.2017.12825541282554Influence of PEG coating on the oral bioavailability of gold nanoparticles in ratsAhmed Alalaiwe0Georgia Roberts1Paul Carpinone2John Munson3Stephen Roberts4College of Pharmacy, University of FloridaCenter for Environmental and Human Toxicology, University of FloridaMajor Analytical and Particle Analysis Instrumentation Centers, University of FloridaCenter for Environmental and Human Toxicology, University of FloridaCenter for Environmental and Human Toxicology, University of FloridaMetallic nanoparticles can be produced in a variety of shapes, sizes, and surface chemistries, making them promising potential tools for drug delivery. Most studies to date have evaluated uptake of metallic nanoparticles from the GI tract with methods that are at best semi-quantitative. This study used the classical method of comparing blood concentration area under the curve (AUC) following intravenous and oral doses to determine the oral bioavailability of 1, 2 and 5 kDa PEG-coated 5 nm gold nanoparticles (AuNPs). Male rats were given a single intravenous dose (0.8 mg/kg) or oral (gavage) dose (8 mg/kg) of a PEG-coated AuNP, and the concentration of gold was measured in blood over time and in tissues (liver, spleen and kidney) at sacrifice. Blood concentrations following oral administration were inversely related to PEG size, and the AUC in blood was significantly greater for the 1 kDa PEG-coated AuNPs than particles coated with 2 or 5 kDa PEG. However, bioavailabilities of all of the particles were very low (< 0.1%). Concentrations in liver, spleen and kidney were similar after the intravenous doses, but kidney showed the highest concentrations after an oral dose. In addition to providing information on the bioavailability of AuNPs coated with PEG in the 1–5 kDa range, this study demonstrates the utility of applying the blood AUC approach to assess the quantitative oral bioavailability of metallic nanoparticles.http://dx.doi.org/10.1080/10717544.2017.1282554gold nanoparticlesoral bioavailabilitypolyethylene glycol (peg)metallic nanoparticlesbioavailability assessment |
| spellingShingle | Ahmed Alalaiwe Georgia Roberts Paul Carpinone John Munson Stephen Roberts Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats Drug Delivery gold nanoparticles oral bioavailability polyethylene glycol (peg) metallic nanoparticles bioavailability assessment |
| title | Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats |
| title_full | Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats |
| title_fullStr | Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats |
| title_full_unstemmed | Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats |
| title_short | Influence of PEG coating on the oral bioavailability of gold nanoparticles in rats |
| title_sort | influence of peg coating on the oral bioavailability of gold nanoparticles in rats |
| topic | gold nanoparticles oral bioavailability polyethylene glycol (peg) metallic nanoparticles bioavailability assessment |
| url | http://dx.doi.org/10.1080/10717544.2017.1282554 |
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