SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence
Background: We conducted this review to summarize the relation between viral mutation and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method: Articles were identified through a literature search until 31 May 2021, in PubMed, Web of Science and Google Scholar. Re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/12/2635 |
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| author | Thi Loi Dao Van Thuan Hoang Philippe Colson Jean Christophe Lagier Matthieu Million Didier Raoult Anthony Levasseur Philippe Gautret |
| author_facet | Thi Loi Dao Van Thuan Hoang Philippe Colson Jean Christophe Lagier Matthieu Million Didier Raoult Anthony Levasseur Philippe Gautret |
| author_sort | Thi Loi Dao |
| collection | DOAJ |
| description | Background: We conducted this review to summarize the relation between viral mutation and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method: Articles were identified through a literature search until 31 May 2021, in PubMed, Web of Science and Google Scholar. Results: Sixty-three studies were included. To date, most studies showed that the viral mutations, especially the D614G variant, correlate with a higher infectivity than the wild-type virus. However, the evidence of the association between viral mutation and severity of the disease is scant. A SARS-CoV-2 variant with a 382-nucleotide deletion was associated with less severe infection in patients. The 11,083G > U mutation was significantly associated with asymptomatic patients. By contrast, ORF1ab 4715L and S protein 614G variants were significantly more frequent in patients from countries where high fatality rates were also reported. The current evidence showed that variants of concern have led to increased infectivity and deteriorating epidemiological situations. However, the relation between this variant and severity of COVID-19 infection was contradictory. Conclusion: The COVID-19 pandemic continues to spread worldwide. It is necessary to anticipate large clinical cohorts to evaluate the virulence and transmissibility of SARS-CoV-2 mutants. |
| first_indexed | 2024-03-10T10:23:07Z |
| format | Article |
| id | doaj.art-1a8db1dab6a34218b7ba225db17060ef |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:23:07Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1a8db1dab6a34218b7ba225db17060ef2023-11-22T00:12:40ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011012263510.3390/jcm10122635SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current EvidenceThi Loi Dao0Van Thuan Hoang1Philippe Colson2Jean Christophe Lagier3Matthieu Million4Didier Raoult5Anthony Levasseur6Philippe Gautret7IRD, AP-HM, SSA, VITROME, Aix Marseille University, 13005 Marseille, FranceIRD, AP-HM, SSA, VITROME, Aix Marseille University, 13005 Marseille, FranceIHU—Méditerranée Infection, Aix Marseille University, 13005 Marseille, FranceIHU—Méditerranée Infection, Aix Marseille University, 13005 Marseille, FranceIHU—Méditerranée Infection, Aix Marseille University, 13005 Marseille, FranceIHU—Méditerranée Infection, Aix Marseille University, 13005 Marseille, FranceIHU—Méditerranée Infection, Aix Marseille University, 13005 Marseille, FranceIRD, AP-HM, SSA, VITROME, Aix Marseille University, 13005 Marseille, FranceBackground: We conducted this review to summarize the relation between viral mutation and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method: Articles were identified through a literature search until 31 May 2021, in PubMed, Web of Science and Google Scholar. Results: Sixty-three studies were included. To date, most studies showed that the viral mutations, especially the D614G variant, correlate with a higher infectivity than the wild-type virus. However, the evidence of the association between viral mutation and severity of the disease is scant. A SARS-CoV-2 variant with a 382-nucleotide deletion was associated with less severe infection in patients. The 11,083G > U mutation was significantly associated with asymptomatic patients. By contrast, ORF1ab 4715L and S protein 614G variants were significantly more frequent in patients from countries where high fatality rates were also reported. The current evidence showed that variants of concern have led to increased infectivity and deteriorating epidemiological situations. However, the relation between this variant and severity of COVID-19 infection was contradictory. Conclusion: The COVID-19 pandemic continues to spread worldwide. It is necessary to anticipate large clinical cohorts to evaluate the virulence and transmissibility of SARS-CoV-2 mutants.https://www.mdpi.com/2077-0383/10/12/2635SARS-CoV-2COVID-19mutantsvariantsinfectivityseverity |
| spellingShingle | Thi Loi Dao Van Thuan Hoang Philippe Colson Jean Christophe Lagier Matthieu Million Didier Raoult Anthony Levasseur Philippe Gautret SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence Journal of Clinical Medicine SARS-CoV-2 COVID-19 mutants variants infectivity severity |
| title | SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence |
| title_full | SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence |
| title_fullStr | SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence |
| title_full_unstemmed | SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence |
| title_short | SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence |
| title_sort | sars cov 2 infectivity and severity of covid 19 according to sars cov 2 variants current evidence |
| topic | SARS-CoV-2 COVID-19 mutants variants infectivity severity |
| url | https://www.mdpi.com/2077-0383/10/12/2635 |
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