The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract
This study was undertaken to evaluate the effect of the <i>BCO2</i> genotype and dietary supplementation with marigold flower extract on the expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in the adipose tissue an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/3/2304 |
| Summary: | This study was undertaken to evaluate the effect of the <i>BCO2</i> genotype and dietary supplementation with marigold flower extract on the expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in the adipose tissue and brain of rabbits. The concentrations of lutein, zeaxanthin, β-carotene, retinol, and α-tocopherol were determined in samples collected from rabbits. Sixty young male Termond White rabbits were allocated to three groups based on their genotype at codon 248 of the <i>BCO2</i> gene (ins/ins, ins/del, and del/del). Each group comprised two subgroups; one subgroup was administered a standard diet, whereas the diet offered to the other subgroup was supplemented with 6 g/kg of marigold flower extract. The study demonstrated that the <i>BCO2</i> genotype may influence the expression levels of the <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and <i>TTPA</i> and <i>BCO1</i> genes in the brain. Moreover, an increase in the amount of lutein in the diet of BCO2 del/del rabbits may increase the expression of <i>BCO1</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and the expression of the <i>BCO2</i> gene in the brain. Another finding of the study is that the content of carotenoids and α-tocopherol increases in both the adipose tissue and brain of <i>BCO2</i> del/del rabbits. |
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| ISSN: | 1661-6596 1422-0067 |