The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract
This study was undertaken to evaluate the effect of the <i>BCO2</i> genotype and dietary supplementation with marigold flower extract on the expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in the adipose tissue an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2304 |
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| author | Janusz Strychalski Andrzej Gugołek Edyta Kaczorek-Łukowska Zofia Antoszkiewicz Paulius Matusevičius |
| author_facet | Janusz Strychalski Andrzej Gugołek Edyta Kaczorek-Łukowska Zofia Antoszkiewicz Paulius Matusevičius |
| author_sort | Janusz Strychalski |
| collection | DOAJ |
| description | This study was undertaken to evaluate the effect of the <i>BCO2</i> genotype and dietary supplementation with marigold flower extract on the expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in the adipose tissue and brain of rabbits. The concentrations of lutein, zeaxanthin, β-carotene, retinol, and α-tocopherol were determined in samples collected from rabbits. Sixty young male Termond White rabbits were allocated to three groups based on their genotype at codon 248 of the <i>BCO2</i> gene (ins/ins, ins/del, and del/del). Each group comprised two subgroups; one subgroup was administered a standard diet, whereas the diet offered to the other subgroup was supplemented with 6 g/kg of marigold flower extract. The study demonstrated that the <i>BCO2</i> genotype may influence the expression levels of the <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and <i>TTPA</i> and <i>BCO1</i> genes in the brain. Moreover, an increase in the amount of lutein in the diet of BCO2 del/del rabbits may increase the expression of <i>BCO1</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and the expression of the <i>BCO2</i> gene in the brain. Another finding of the study is that the content of carotenoids and α-tocopherol increases in both the adipose tissue and brain of <i>BCO2</i> del/del rabbits. |
| first_indexed | 2024-03-11T09:41:32Z |
| format | Article |
| id | doaj.art-1a904ea32a2b4614a692c8b29305db7c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:41:32Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1a904ea32a2b4614a692c8b29305db7c2023-11-16T16:55:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243230410.3390/ijms24032304The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower ExtractJanusz Strychalski0Andrzej Gugołek1Edyta Kaczorek-Łukowska2Zofia Antoszkiewicz3Paulius Matusevičius4Department of Fur-Bearing Animal Breeding and Game Management, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, PolandDepartment of Fur-Bearing Animal Breeding and Game Management, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, PolandDepartment of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-719 Olsztyn, PolandDepartment of Animal Nutrition and Feed Science, University of Warmia and Mazury in Olsztyn, Oczapowskiego 5, 10-719 Olsztyn, PolandDepartment of Animal Breeding and Nutrition, Faculty of Animal Husbandry Technology, Lithuanian University of Health Sciences, Tilžes 18, LT-47181 Kaunas, LithuaniaThis study was undertaken to evaluate the effect of the <i>BCO2</i> genotype and dietary supplementation with marigold flower extract on the expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in the adipose tissue and brain of rabbits. The concentrations of lutein, zeaxanthin, β-carotene, retinol, and α-tocopherol were determined in samples collected from rabbits. Sixty young male Termond White rabbits were allocated to three groups based on their genotype at codon 248 of the <i>BCO2</i> gene (ins/ins, ins/del, and del/del). Each group comprised two subgroups; one subgroup was administered a standard diet, whereas the diet offered to the other subgroup was supplemented with 6 g/kg of marigold flower extract. The study demonstrated that the <i>BCO2</i> genotype may influence the expression levels of the <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and <i>TTPA</i> and <i>BCO1</i> genes in the brain. Moreover, an increase in the amount of lutein in the diet of BCO2 del/del rabbits may increase the expression of <i>BCO1</i>, <i>LRAT,</i> and <i>TTPA</i> genes in adipose tissue, and the expression of the <i>BCO2</i> gene in the brain. Another finding of the study is that the content of carotenoids and α-tocopherol increases in both the adipose tissue and brain of <i>BCO2</i> del/del rabbits.https://www.mdpi.com/1422-0067/24/3/2304<i>BCO2</i> generabbitsmarigoldgene expressioncarotenoids |
| spellingShingle | Janusz Strychalski Andrzej Gugołek Edyta Kaczorek-Łukowska Zofia Antoszkiewicz Paulius Matusevičius The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract International Journal of Molecular Sciences <i>BCO2</i> gene rabbits marigold gene expression carotenoids |
| title | The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract |
| title_full | The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract |
| title_fullStr | The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract |
| title_full_unstemmed | The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract |
| title_short | The <i>BCO2</i> Genotype and the Expression of <i>BCO1</i>, <i>BCO2</i>, <i>LRAT,</i> and <i>TTPA</i> Genes in the Adipose Tissue and Brain of Rabbits Fed a Diet with Marigold Flower Extract |
| title_sort | i bco2 i genotype and the expression of i bco1 i i bco2 i i lrat i and i ttpa i genes in the adipose tissue and brain of rabbits fed a diet with marigold flower extract |
| topic | <i>BCO2</i> gene rabbits marigold gene expression carotenoids |
| url | https://www.mdpi.com/1422-0067/24/3/2304 |
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