Mechanisms of Oocyte Maturation and Related Epigenetic Regulation
Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins-induced ovulation happens. Once meiosis gets started, the oocytes undergo the leptotene, zygotene, and pachytene stages...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.654028/full |
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| author | Meina He Meina He Meina He Tuo Zhang Tuo Zhang Tuo Zhang Yi Yang Chao Wang Chao Wang |
| author_facet | Meina He Meina He Meina He Tuo Zhang Tuo Zhang Tuo Zhang Yi Yang Chao Wang Chao Wang |
| author_sort | Meina He |
| collection | DOAJ |
| description | Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins-induced ovulation happens. Once meiosis gets started, the oocytes undergo the leptotene, zygotene, and pachytene stages, and then arrest at the dictyate stage. During each estrus cycle in mammals, or menstrual cycle in humans, a small portion of oocytes within preovulatory follicles may resume meiosis. It is crucial for females to supply high quality mature oocytes for sustaining fertility, which is generally achieved by fine-tuning oocyte meiotic arrest and resumption progression. Anything that disturbs the process may result in failure of oogenesis and seriously affect both the fertility and the health of females. Therefore, uncovering the regulatory network of oocyte meiosis progression illuminates not only how the foundations of mammalian reproduction are laid, but how mis-regulation of these steps result in infertility. In order to provide an overview of the recently uncovered cellular and molecular mechanism during oocyte maturation, especially epigenetic modification, the progress of the regulatory network of oocyte meiosis progression including meiosis arrest and meiosis resumption induced by gonadotropins is summarized. Then, advances in the epigenetic aspects, such as histone acetylation, phosphorylation, methylation, glycosylation, ubiquitination, and SUMOylation related to the quality of oocyte maturation are reviewed. |
| first_indexed | 2024-12-16T15:06:00Z |
| format | Article |
| id | doaj.art-1a9194d896f943b0b830caccccb96cb2 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T15:06:00Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1a9194d896f943b0b830caccccb96cb22022-12-21T22:27:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.654028654028Mechanisms of Oocyte Maturation and Related Epigenetic RegulationMeina He0Meina He1Meina He2Tuo Zhang3Tuo Zhang4Tuo Zhang5Yi Yang6Chao Wang7Chao Wang8Department of Biology, School of Basic Medical Science, Guizhou Medical University, Guiyang, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, ChinaKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, College of Life Science, Ningxia University, Yinchuan, ChinaDepartment of Physiology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, ChinaKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, College of Life Science, Ningxia University, Yinchuan, ChinaKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, College of Life Science, Ningxia University, Yinchuan, ChinaState Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, ChinaKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western China, College of Life Science, Ningxia University, Yinchuan, ChinaMeiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins-induced ovulation happens. Once meiosis gets started, the oocytes undergo the leptotene, zygotene, and pachytene stages, and then arrest at the dictyate stage. During each estrus cycle in mammals, or menstrual cycle in humans, a small portion of oocytes within preovulatory follicles may resume meiosis. It is crucial for females to supply high quality mature oocytes for sustaining fertility, which is generally achieved by fine-tuning oocyte meiotic arrest and resumption progression. Anything that disturbs the process may result in failure of oogenesis and seriously affect both the fertility and the health of females. Therefore, uncovering the regulatory network of oocyte meiosis progression illuminates not only how the foundations of mammalian reproduction are laid, but how mis-regulation of these steps result in infertility. In order to provide an overview of the recently uncovered cellular and molecular mechanism during oocyte maturation, especially epigenetic modification, the progress of the regulatory network of oocyte meiosis progression including meiosis arrest and meiosis resumption induced by gonadotropins is summarized. Then, advances in the epigenetic aspects, such as histone acetylation, phosphorylation, methylation, glycosylation, ubiquitination, and SUMOylation related to the quality of oocyte maturation are reviewed.https://www.frontiersin.org/articles/10.3389/fcell.2021.654028/fullovaryoocytemeiosis arrestmeiosis resumptionoocyte maturation |
| spellingShingle | Meina He Meina He Meina He Tuo Zhang Tuo Zhang Tuo Zhang Yi Yang Chao Wang Chao Wang Mechanisms of Oocyte Maturation and Related Epigenetic Regulation Frontiers in Cell and Developmental Biology ovary oocyte meiosis arrest meiosis resumption oocyte maturation |
| title | Mechanisms of Oocyte Maturation and Related Epigenetic Regulation |
| title_full | Mechanisms of Oocyte Maturation and Related Epigenetic Regulation |
| title_fullStr | Mechanisms of Oocyte Maturation and Related Epigenetic Regulation |
| title_full_unstemmed | Mechanisms of Oocyte Maturation and Related Epigenetic Regulation |
| title_short | Mechanisms of Oocyte Maturation and Related Epigenetic Regulation |
| title_sort | mechanisms of oocyte maturation and related epigenetic regulation |
| topic | ovary oocyte meiosis arrest meiosis resumption oocyte maturation |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.654028/full |
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