Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power
Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnsys.2017.00038/full |
| _version_ | 1818253963572543488 |
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| author | Kara J. Pavone Kara J. Pavone Lijuan Su Lijuan Su Lei Gao Ersne Eromo Rafael Vazquez James Rhee Lauren E. Hobbs Reine Ibala Gizem Demircioglu Patrick L. Purdon Emery N. Brown Emery N. Brown Oluwaseun Akeju |
| author_facet | Kara J. Pavone Kara J. Pavone Lijuan Su Lijuan Su Lei Gao Ersne Eromo Rafael Vazquez James Rhee Lauren E. Hobbs Reine Ibala Gizem Demircioglu Patrick L. Purdon Emery N. Brown Emery N. Brown Oluwaseun Akeju |
| author_sort | Kara J. Pavone |
| collection | DOAJ |
| description | Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest that by disrupting the oscillatory dynamics that are associated with arousal states, anesthesia-induced oscillations are a putative mechanism through which anesthetic drugs produce altered states of arousal. However, an empirical clinical observation is that even at relatively stable anesthetic doses, patients are sometimes intermittently responsive to verbal commands during states of light sedation. During these periods, prominent anesthesia-induced neural oscillations such as slow-delta (0.1–4 Hz) oscillations are notably absent. Neural correlates of intermittent responsiveness during light sedation have been insufficiently investigated. A principled understanding of the neural correlates of intermittent responsiveness may fundamentally advance our understanding of neural dynamics that are essential for maintaining arousal states, and how they are disrupted by anesthetics. Therefore, we performed a high-density (128 channels) electroencephalogram (EEG) study (n = 8) of sevoflurane-induced altered arousal in healthy volunteers. We administered temporally precise behavioral stimuli every 5 s to assess responsiveness. Here, we show that decreased eyes-closed, awake-alpha (8–12 Hz) oscillation power is associated with lack of responsiveness during sevoflurane effect-onset and -offset. We also show that anteriorization—the transition from occipitally dominant awake-alpha oscillations to frontally dominant anesthesia induced-alpha oscillations—is not a binary phenomenon. Rather, we suggest that periods, which were defined by lack of responsiveness, represent an intermediate brain state. We conclude that awake-alpha oscillation, previously thought to be an idling rhythm, is associated with responsiveness to behavioral stimuli. |
| first_indexed | 2024-12-12T16:48:25Z |
| format | Article |
| id | doaj.art-1a92bca80bfe41eebaa652615c6ccef0 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-12T16:48:25Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-1a92bca80bfe41eebaa652615c6ccef02022-12-22T00:18:25ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372017-05-011110.3389/fnsys.2017.00038260798Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation PowerKara J. Pavone0Kara J. Pavone1Lijuan Su2Lijuan Su3Lei Gao4Ersne Eromo5Rafael Vazquez6James Rhee7Lauren E. Hobbs8Reine Ibala9Gizem Demircioglu10Patrick L. Purdon11Emery N. Brown12Emery N. Brown13Oluwaseun Akeju14Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesSchool of Nursing, University of PennsylvaniaPhiladelphia, PA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Computer Science, Zhejiang UniversityHangzhou, ChinaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesHarvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of TechnologyCambridge, MA, United StatesDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical SchoolBoston, MA, United StatesAnesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest that by disrupting the oscillatory dynamics that are associated with arousal states, anesthesia-induced oscillations are a putative mechanism through which anesthetic drugs produce altered states of arousal. However, an empirical clinical observation is that even at relatively stable anesthetic doses, patients are sometimes intermittently responsive to verbal commands during states of light sedation. During these periods, prominent anesthesia-induced neural oscillations such as slow-delta (0.1–4 Hz) oscillations are notably absent. Neural correlates of intermittent responsiveness during light sedation have been insufficiently investigated. A principled understanding of the neural correlates of intermittent responsiveness may fundamentally advance our understanding of neural dynamics that are essential for maintaining arousal states, and how they are disrupted by anesthetics. Therefore, we performed a high-density (128 channels) electroencephalogram (EEG) study (n = 8) of sevoflurane-induced altered arousal in healthy volunteers. We administered temporally precise behavioral stimuli every 5 s to assess responsiveness. Here, we show that decreased eyes-closed, awake-alpha (8–12 Hz) oscillation power is associated with lack of responsiveness during sevoflurane effect-onset and -offset. We also show that anteriorization—the transition from occipitally dominant awake-alpha oscillations to frontally dominant anesthesia induced-alpha oscillations—is not a binary phenomenon. Rather, we suggest that periods, which were defined by lack of responsiveness, represent an intermediate brain state. We conclude that awake-alpha oscillation, previously thought to be an idling rhythm, is associated with responsiveness to behavioral stimuli.http://journal.frontiersin.org/article/10.3389/fnsys.2017.00038/fullawake-alpha oscillationsloss of consciousnessrecovery of consciousness sevofluranesedationgeneral anesthesia |
| spellingShingle | Kara J. Pavone Kara J. Pavone Lijuan Su Lijuan Su Lei Gao Ersne Eromo Rafael Vazquez James Rhee Lauren E. Hobbs Reine Ibala Gizem Demircioglu Patrick L. Purdon Emery N. Brown Emery N. Brown Oluwaseun Akeju Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power Frontiers in Systems Neuroscience awake-alpha oscillations loss of consciousness recovery of consciousness sevoflurane sedation general anesthesia |
| title | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_full | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_fullStr | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_full_unstemmed | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_short | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_sort | lack of responsiveness during the onset and offset of sevoflurane anesthesia is associated with decreased awake alpha oscillation power |
| topic | awake-alpha oscillations loss of consciousness recovery of consciousness sevoflurane sedation general anesthesia |
| url | http://journal.frontiersin.org/article/10.3389/fnsys.2017.00038/full |
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