DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Abstract Background Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of...

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Bibliographic Details
Main Authors: Gilles Gasparoni, Sebastian Bultmann, Pavlo Lutsik, Theo F. J. Kraus, Sabrina Sordon, Julia Vlcek, Vanessa Dietinger, Martina Steinmaurer, Melanie Haider, Christopher B. Mulholland, Thomas Arzberger, Sigrun Roeber, Matthias Riemenschneider, Hans A. Kretzschmar, Armin Giese, Heinrich Leonhardt, Jörn Walter
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Epigenetics & Chromatin
Subjects:
DNA methylation
Epigenetics
Alzheimer’s disease
Neurodegeneration
Aging
Cell sorting
Online Access:http://link.springer.com/article/10.1186/s13072-018-0211-3

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