Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registry

Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis – data from the German AID-registry

Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinflammatory character of the disease and offering an effective blocking m...

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Main Authors: Elke Lainka, Melanie Baehr, Bernadette Raszka, Johannes-Peter Haas, Boris Hügle, Nadine Fischer, Dirk Foell, Claas Hinze, Elisabeth Weissbarth-Riedel, Tilmann Kallinich, Gerd Horneff, Daniel Windschall, Eggert Lilienthal, Tim Niehues, Ulrich Neudorf, Rainer Berendes, Rolf-Michael Küster, Prasad Thomas Oommen, Christoph Rietschel, Thomas Lutz, Frank Weller-Heinemann, Klaus Tenbrock, Georg Leonhard Heubner, Jens Klotsche, Helmut Wittkowski
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Systemic juvenile idiopathic arthritis
Autoinflammatory disease
Proinflammatory cytokines
Interleukin-1
Anakinra
Canakinumab
Online Access:https://doi.org/10.1186/s12969-021-00510-8

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