Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918.
The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although the symptoms in humans are mild at present, fears are that further mutations in the virus could lead to a potentially more dangerous outbreak in subsequent months. As the primary immunity-eliciting an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-11-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2773012?pdf=render |
| _version_ | 1811330437474156544 |
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| author | Jun Shen Jianpeng Ma Qinghua Wang |
| author_facet | Jun Shen Jianpeng Ma Qinghua Wang |
| author_sort | Jun Shen |
| collection | DOAJ |
| description | The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although the symptoms in humans are mild at present, fears are that further mutations in the virus could lead to a potentially more dangerous outbreak in subsequent months. As the primary immunity-eliciting antigen, hemagglutinin (HA) is the major agent for host-driven antigenic drift in A(H3N2) virus. However, whether and how the evolution of HA is influenced by existing immunity is poorly understood for A(H1N1). Here, by analyzing hundreds of A(H1N1) HA sequences since 1918, we show the first evidence that host selections are indeed present in A(H1N1) HAs. Among a subgroup of human A(H1N1) HAs between 1918 approximately 2008, we found strong diversifying (positive) selection at HA(1) 156 and 190. We also analyzed the evolutionary trends at HA(1) 190 and 225 that are critical determinants for receptor-binding specificity of A(H1N1) HA. Different A(H1N1) viruses appeared to favor one of these two sites in host-driven antigenic drift: epidemic A(H1N1) HAs favor HA(1) 190 while the 1918 pandemic and swine HAs favor HA(1) 225. Thus, our results highlight the urgency to understand the interplay between antigenic drift and receptor binding in HA evolution, and provide molecular signatures for monitoring future antigenically drifted 2009 pandemic and seasonal A(H1N1) influenza viruses. |
| first_indexed | 2024-04-13T16:01:30Z |
| format | Article |
| id | doaj.art-1a9444093d534d998cad13cae366a6d8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T16:01:30Z |
| publishDate | 2009-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a9444093d534d998cad13cae366a6d82022-12-22T02:40:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-11-01411e778910.1371/journal.pone.0007789Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918.Jun ShenJianpeng MaQinghua WangThe Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although the symptoms in humans are mild at present, fears are that further mutations in the virus could lead to a potentially more dangerous outbreak in subsequent months. As the primary immunity-eliciting antigen, hemagglutinin (HA) is the major agent for host-driven antigenic drift in A(H3N2) virus. However, whether and how the evolution of HA is influenced by existing immunity is poorly understood for A(H1N1). Here, by analyzing hundreds of A(H1N1) HA sequences since 1918, we show the first evidence that host selections are indeed present in A(H1N1) HAs. Among a subgroup of human A(H1N1) HAs between 1918 approximately 2008, we found strong diversifying (positive) selection at HA(1) 156 and 190. We also analyzed the evolutionary trends at HA(1) 190 and 225 that are critical determinants for receptor-binding specificity of A(H1N1) HA. Different A(H1N1) viruses appeared to favor one of these two sites in host-driven antigenic drift: epidemic A(H1N1) HAs favor HA(1) 190 while the 1918 pandemic and swine HAs favor HA(1) 225. Thus, our results highlight the urgency to understand the interplay between antigenic drift and receptor binding in HA evolution, and provide molecular signatures for monitoring future antigenically drifted 2009 pandemic and seasonal A(H1N1) influenza viruses.http://europepmc.org/articles/PMC2773012?pdf=render |
| spellingShingle | Jun Shen Jianpeng Ma Qinghua Wang Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. PLoS ONE |
| title | Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. |
| title_full | Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. |
| title_fullStr | Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. |
| title_full_unstemmed | Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. |
| title_short | Evolutionary trends of A(H1N1) influenza virus hemagglutinin since 1918. |
| title_sort | evolutionary trends of a h1n1 influenza virus hemagglutinin since 1918 |
| url | http://europepmc.org/articles/PMC2773012?pdf=render |
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