Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial
Abstract Objectives Women with a history of gestational diabetes (GDM) are at 7-fold increase in the risk of developing diabetes. Insufficient sleep has also been shown to increase diabetes risk. This study aimed to explore the feasibility of a sleep extension in women with a history of GDM and shor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | Pilot and Feasibility Studies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40814-022-01076-2 |
| _version_ | 1818202735652110336 |
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| author | Sirimon Reutrakul Pamela Martyn-Nemeth Lauretta Quinn Brett Rydzon Medha Priyadarshini Kirstie K. Danielson Kelly G. Baron Jennifer Duffecy |
| author_facet | Sirimon Reutrakul Pamela Martyn-Nemeth Lauretta Quinn Brett Rydzon Medha Priyadarshini Kirstie K. Danielson Kelly G. Baron Jennifer Duffecy |
| author_sort | Sirimon Reutrakul |
| collection | DOAJ |
| description | Abstract Objectives Women with a history of gestational diabetes (GDM) are at 7-fold increase in the risk of developing diabetes. Insufficient sleep has also been shown to increase diabetes risk. This study aimed to explore the feasibility of a sleep extension in women with a history of GDM and short sleep, and effects on glucose metabolism. Methods Women age 18–45 years with a history of GDM and actigraphy confirmed short sleep duration (<7 h/night) on weekdays were randomized at a ratio of 1 control (heathy living information) to 2 cases (6 weeks of “Sleep-Extend” intervention: use of a Fitbit, weekly digital content, and weekly coaching to increase sleep duration). An oral glucose tolerance test (OGTT), 7-day actigraphy recording, and questionnaires were obtained at baseline and 6 weeks. Mean differences between baseline and end-of-intervention parameters were compared using independent samples t-tests. Results Mean (SD) sleep duration increased within the Sleep-Extend group (n=9, +26.9 (42.5) min) but decreased within the controls (n=5, − 9.1 (20.4) min), a mean difference (MD) of 35.9 min (95% confidence interval (CI) − 8.6, 80.5). Fasting glucose increased, but less in Sleep-Extend vs. control groups (1.6 (9.4) vs 10.4 (8.2) mg/dL, MD − 8.8 mg/dL (95% CI − 19.8, 2.1), while 2-h glucose levels after an OGTT did not differ. Compared to controls, Sleep-Extend had decreased fatigue score (MD − 10.6, 95%CI − 20.7, − 0.6), and increased self-report physical activity (MD 5036 MET- minutes/week, 95%CI 343, 9729. Fitbit compliance and satisfaction in Sleep-Extend group was high. Conclusion Sleep extension is feasible in women with a history of GDM, with benefits in fatigue and physical activity, and possibly glucose metabolism. These data support a larger study exploring benefits of sleep extension on glucose metabolism in these high-risk women. Trial registration ClinicalTrials.gov , NCT03638102 (8/20/2018) |
| first_indexed | 2024-12-12T03:14:10Z |
| format | Article |
| id | doaj.art-1a94e109c86a43708df8d81a57ccf151 |
| institution | Directory Open Access Journal |
| issn | 2055-5784 |
| language | English |
| last_indexed | 2024-12-12T03:14:10Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Pilot and Feasibility Studies |
| spelling | doaj.art-1a94e109c86a43708df8d81a57ccf1512022-12-22T00:40:19ZengBMCPilot and Feasibility Studies2055-57842022-06-01811910.1186/s40814-022-01076-2Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trialSirimon Reutrakul0Pamela Martyn-Nemeth1Lauretta Quinn2Brett Rydzon3Medha Priyadarshini4Kirstie K. Danielson5Kelly G. Baron6Jennifer Duffecy7Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at ChicagoDepartment of Biobehavioral Nursing Science, College of Nursing, University of Illinois at ChicagoDepartment of Biobehavioral Nursing Science, College of Nursing, University of Illinois at ChicagoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at ChicagoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at ChicagoDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at ChicagoDivision of Public Health, Department of Family and Preventive Medicine, The University of UtahDepartment of Psychiatry, University of Illinois at ChicagoAbstract Objectives Women with a history of gestational diabetes (GDM) are at 7-fold increase in the risk of developing diabetes. Insufficient sleep has also been shown to increase diabetes risk. This study aimed to explore the feasibility of a sleep extension in women with a history of GDM and short sleep, and effects on glucose metabolism. Methods Women age 18–45 years with a history of GDM and actigraphy confirmed short sleep duration (<7 h/night) on weekdays were randomized at a ratio of 1 control (heathy living information) to 2 cases (6 weeks of “Sleep-Extend” intervention: use of a Fitbit, weekly digital content, and weekly coaching to increase sleep duration). An oral glucose tolerance test (OGTT), 7-day actigraphy recording, and questionnaires were obtained at baseline and 6 weeks. Mean differences between baseline and end-of-intervention parameters were compared using independent samples t-tests. Results Mean (SD) sleep duration increased within the Sleep-Extend group (n=9, +26.9 (42.5) min) but decreased within the controls (n=5, − 9.1 (20.4) min), a mean difference (MD) of 35.9 min (95% confidence interval (CI) − 8.6, 80.5). Fasting glucose increased, but less in Sleep-Extend vs. control groups (1.6 (9.4) vs 10.4 (8.2) mg/dL, MD − 8.8 mg/dL (95% CI − 19.8, 2.1), while 2-h glucose levels after an OGTT did not differ. Compared to controls, Sleep-Extend had decreased fatigue score (MD − 10.6, 95%CI − 20.7, − 0.6), and increased self-report physical activity (MD 5036 MET- minutes/week, 95%CI 343, 9729. Fitbit compliance and satisfaction in Sleep-Extend group was high. Conclusion Sleep extension is feasible in women with a history of GDM, with benefits in fatigue and physical activity, and possibly glucose metabolism. These data support a larger study exploring benefits of sleep extension on glucose metabolism in these high-risk women. Trial registration ClinicalTrials.gov , NCT03638102 (8/20/2018)https://doi.org/10.1186/s40814-022-01076-2Gestational diabetesSleep extensionGlucoseSleep durationShort sleep |
| spellingShingle | Sirimon Reutrakul Pamela Martyn-Nemeth Lauretta Quinn Brett Rydzon Medha Priyadarshini Kirstie K. Danielson Kelly G. Baron Jennifer Duffecy Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial Pilot and Feasibility Studies Gestational diabetes Sleep extension Glucose Sleep duration Short sleep |
| title | Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial |
| title_full | Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial |
| title_fullStr | Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial |
| title_full_unstemmed | Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial |
| title_short | Effects of Sleep-Extend on glucose metabolism in women with a history of gestational diabetes: a pilot randomized trial |
| title_sort | effects of sleep extend on glucose metabolism in women with a history of gestational diabetes a pilot randomized trial |
| topic | Gestational diabetes Sleep extension Glucose Sleep duration Short sleep |
| url | https://doi.org/10.1186/s40814-022-01076-2 |
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