Case report: Hemangioblastoma in the brainstem of a dog
A 3-year-old castrated male, American Pit Bull Terrier presented to Texas A&M University due to a 3-week mixed cerebellar and general proprioceptive ataxia, circling, head tilt, and dull mentation. Neurologic examination revealed signs of vestibular and mesencephalic dysfunction. Postmortem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1126477/full |
| _version_ | 1827985677407485952 |
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| author | Kirsten Landsgaard Samantha St. Jean Stephanie Lovell Jonathan Levine Christine Gremillion Brian Summers Raquel R. Rech |
| author_facet | Kirsten Landsgaard Samantha St. Jean Stephanie Lovell Jonathan Levine Christine Gremillion Brian Summers Raquel R. Rech |
| author_sort | Kirsten Landsgaard |
| collection | DOAJ |
| description | A 3-year-old castrated male, American Pit Bull Terrier presented to Texas A&M University due to a 3-week mixed cerebellar and general proprioceptive ataxia, circling, head tilt, and dull mentation. Neurologic examination revealed signs of vestibular and mesencephalic dysfunction. Postmortem examination revealed a 1.1 × 1 × 0.8-cm, soft, dark red, well-circumscribed, left-sided mass, extending from the crus cerebri of the midbrain caudally to the pons. Microscopically, the neoplasm was composed of a spindle-shaped interstitial population of cells interspersed between a prominent capillary network, consistent with the reticular pattern of hemangioblastoma. Interstitial cells had strong, diffuse, intracytoplasmic immunolabeling for neuron-specific enolase (NSE) and were variably positive for intracytoplasmic glial fibrillary acidic protein (GFAP). Vascular endothelial cells had strong diffuse, intracytoplasmic immunolabeling for von Willebrand factor (VWF) glycoprotein. To date, only six cases of hemangioblastoma have been reported in canines, five in the spinal cord, and one in the rostral cerebrum. Our case may represent the first canine hemangioblastoma localized to the brainstem. |
| first_indexed | 2024-04-09T23:18:13Z |
| format | Article |
| id | doaj.art-1a96ef33041647778b1da436aec317d5 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-09T23:18:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-1a96ef33041647778b1da436aec317d52023-03-22T05:17:22ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-03-011010.3389/fvets.2023.11264771126477Case report: Hemangioblastoma in the brainstem of a dogKirsten Landsgaard0Samantha St. Jean1Stephanie Lovell2Jonathan Levine3Christine Gremillion4Brian Summers5Raquel R. Rech6Department of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesDepartment of Large Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesSchool of Veterinary Medicine, University of Melbourne, Werribee, VIC, AustraliaDepartment of Veterinary Pathobiology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, United StatesA 3-year-old castrated male, American Pit Bull Terrier presented to Texas A&M University due to a 3-week mixed cerebellar and general proprioceptive ataxia, circling, head tilt, and dull mentation. Neurologic examination revealed signs of vestibular and mesencephalic dysfunction. Postmortem examination revealed a 1.1 × 1 × 0.8-cm, soft, dark red, well-circumscribed, left-sided mass, extending from the crus cerebri of the midbrain caudally to the pons. Microscopically, the neoplasm was composed of a spindle-shaped interstitial population of cells interspersed between a prominent capillary network, consistent with the reticular pattern of hemangioblastoma. Interstitial cells had strong, diffuse, intracytoplasmic immunolabeling for neuron-specific enolase (NSE) and were variably positive for intracytoplasmic glial fibrillary acidic protein (GFAP). Vascular endothelial cells had strong diffuse, intracytoplasmic immunolabeling for von Willebrand factor (VWF) glycoprotein. To date, only six cases of hemangioblastoma have been reported in canines, five in the spinal cord, and one in the rostral cerebrum. Our case may represent the first canine hemangioblastoma localized to the brainstem.https://www.frontiersin.org/articles/10.3389/fvets.2023.1126477/fullblood vesselbraincentral nervous systemcaninecase report |
| spellingShingle | Kirsten Landsgaard Samantha St. Jean Stephanie Lovell Jonathan Levine Christine Gremillion Brian Summers Raquel R. Rech Case report: Hemangioblastoma in the brainstem of a dog Frontiers in Veterinary Science blood vessel brain central nervous system canine case report |
| title | Case report: Hemangioblastoma in the brainstem of a dog |
| title_full | Case report: Hemangioblastoma in the brainstem of a dog |
| title_fullStr | Case report: Hemangioblastoma in the brainstem of a dog |
| title_full_unstemmed | Case report: Hemangioblastoma in the brainstem of a dog |
| title_short | Case report: Hemangioblastoma in the brainstem of a dog |
| title_sort | case report hemangioblastoma in the brainstem of a dog |
| topic | blood vessel brain central nervous system canine case report |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1126477/full |
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