Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review
Lambert‐Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small‐cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinom...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-05-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.13385 |
| _version_ | 1811299528390737920 |
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| author | Aili Wang Xin Zhang Jiawen Yi Min Zhu Yuhui Zhang |
| author_facet | Aili Wang Xin Zhang Jiawen Yi Min Zhu Yuhui Zhang |
| author_sort | Aili Wang |
| collection | DOAJ |
| description | Lambert‐Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small‐cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinoma complicated with LEMS. In this case, L858R mutation was detected in the 21st exon of the EGFR gene. First‐line treatment with gefitinib was given, and the patient has survived for more than six years. Early diagnosis of LEMS and timely and effective treatment can result in a good prognosis. We also searched for “lung cancer”, or “carcinoma of lung”, or “adenocarcinoma of lung”, or “Lambert‐Eaton myasthenic syndrome” in PubMed until 1 December 2019. Seven cases of lung adenocarcinoma complicated with LEMS were found, most of which had a poor prognosis. Key points This article reports a rare case of metastatic lung adenocarcinoma with EGFR mutation, complicated with LEMS. Gefitinib was given as first‐line treatment, and resulted in a good prognosis. |
| first_indexed | 2024-04-13T06:37:08Z |
| format | Article |
| id | doaj.art-1a9999c30fae440580a73dc1d4d7b06b |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-13T06:37:08Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-1a9999c30fae440580a73dc1d4d7b06b2022-12-22T02:57:52ZengWileyThoracic Cancer1759-77061759-77142020-05-011151334133810.1111/1759-7714.13385Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature reviewAili Wang0Xin Zhang1Jiawen Yi2Min Zhu3Yuhui Zhang4Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital Capital Medical University Beijing ChinaDepartment of Tuberculosis Shijiazhuang Fifth Hospital Hebei ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Chao‐Yang Hospital Capital Medical University, Beijing Institute of Respiratory Medicine Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Chao‐Yang Hospital Capital Medical University, Beijing Institute of Respiratory Medicine Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Beijing Chao‐Yang Hospital Capital Medical University, Beijing Institute of Respiratory Medicine Beijing ChinaLambert‐Eaton myasthenic syndrome (LEMS) is a rare disease characterized by involvement of the neuromuscular junction. Most cases have an underlying malignancy, especially small‐cell lung cancer (SCLC), while adenocarcinoma is less common. Here, we report a rare case of metastatic lung adenocarcinoma complicated with LEMS. In this case, L858R mutation was detected in the 21st exon of the EGFR gene. First‐line treatment with gefitinib was given, and the patient has survived for more than six years. Early diagnosis of LEMS and timely and effective treatment can result in a good prognosis. We also searched for “lung cancer”, or “carcinoma of lung”, or “adenocarcinoma of lung”, or “Lambert‐Eaton myasthenic syndrome” in PubMed until 1 December 2019. Seven cases of lung adenocarcinoma complicated with LEMS were found, most of which had a poor prognosis. Key points This article reports a rare case of metastatic lung adenocarcinoma with EGFR mutation, complicated with LEMS. Gefitinib was given as first‐line treatment, and resulted in a good prognosis.https://doi.org/10.1111/1759-7714.13385Adenocarcinoma of lungLambert‐Eatonmyasthenic syndrome |
| spellingShingle | Aili Wang Xin Zhang Jiawen Yi Min Zhu Yuhui Zhang Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review Thoracic Cancer Adenocarcinoma of lung Lambert‐Eaton myasthenic syndrome |
| title | Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review |
| title_full | Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review |
| title_fullStr | Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review |
| title_full_unstemmed | Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review |
| title_short | Successful treatment of advanced lung adenocarcinoma complicated with Lambert‐Eaton myasthenic syndrome: A case report and literature review |
| title_sort | successful treatment of advanced lung adenocarcinoma complicated with lambert eaton myasthenic syndrome a case report and literature review |
| topic | Adenocarcinoma of lung Lambert‐Eaton myasthenic syndrome |
| url | https://doi.org/10.1111/1759-7714.13385 |
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