SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer

Abstract Invasion and metastasis are the main causes of colorectal cancer (CRC)‐related death. Accumulating evidence suggested that sphingosine kinase 1 (SphK1) promoted the metastasis of CRC and autophagy played an important role in SphK1 promoting the metastasis of malignancy. However, the mechani...

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Bibliographic Details
Main Authors: Jiang‐Ni Wu, Lan Lin, Shi‐Bo Luo, Xin‐Ze Qiu, Li‐Ye Zhu, Da Chen, Er‐Dan Wei, Zhen‐Hua Fu, Meng‐Bin Qin, Zhi‐Hai Liang, Jie‐An Huang, Shi‐Quan Liu
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Cancer Medicine
Subjects:
autophagy
colorectal cancer
metastases
paxillin
sphingosine kinase 1
Online Access:https://doi.org/10.1002/cam4.4129

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