Post-translational modifications of Keap1: the state of the art
The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative stress-induced damage. Its activation entails the expression and transcriptional regulation of several proteins involved in detoxification and antioxidation processes within the organism. Keap1, serving as a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1332049/full |
| _version_ | 1797362289054056448 |
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| author | Yunjia Song Ying Qu Caiyun Mao Rong Zhang Deyou Jiang Xutao Sun |
| author_facet | Yunjia Song Ying Qu Caiyun Mao Rong Zhang Deyou Jiang Xutao Sun |
| author_sort | Yunjia Song |
| collection | DOAJ |
| description | The Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative stress-induced damage. Its activation entails the expression and transcriptional regulation of several proteins involved in detoxification and antioxidation processes within the organism. Keap1, serving as a pivotal transcriptional regulator within this pathway, exerts control over the activity of Nrf2. Various post-translational modifications (PTMs) of Keap1, such as alkylation, glycosylation, glutathiylation, S-sulfhydration, and other modifications, impact the binding affinity between Keap1 and Nrf2. Consequently, this leads to the accumulation of Nrf2 and its translocation to the nucleus, and subsequent activation of downstream antioxidant genes. Given the association between the Keap1-Nrf2 signaling pathway and various diseases such as cancer, neurodegenerative disorders, and diabetes, comprehending the post-translational modification of Keap1 not only deepens our understanding of Nrf2 signaling regulation but also contributes to the identification of novel drug targets and biomarkers. Consequently, this knowledge holds immense importance in the prevention and treatment of diseases induced by oxidative stress. |
| first_indexed | 2024-03-08T16:05:10Z |
| format | Article |
| id | doaj.art-1a99ce73ef044b589d9251ece8a25e31 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T16:05:10Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-1a99ce73ef044b589d9251ece8a25e312024-01-08T06:16:51ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-01-011110.3389/fcell.2023.13320491332049Post-translational modifications of Keap1: the state of the artYunjia Song0Ying Qu1Caiyun Mao2Rong Zhang3Deyou Jiang4Xutao Sun5Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Typhoid, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe Keap1-Nrf2 signaling pathway plays a crucial role in cellular defense against oxidative stress-induced damage. Its activation entails the expression and transcriptional regulation of several proteins involved in detoxification and antioxidation processes within the organism. Keap1, serving as a pivotal transcriptional regulator within this pathway, exerts control over the activity of Nrf2. Various post-translational modifications (PTMs) of Keap1, such as alkylation, glycosylation, glutathiylation, S-sulfhydration, and other modifications, impact the binding affinity between Keap1 and Nrf2. Consequently, this leads to the accumulation of Nrf2 and its translocation to the nucleus, and subsequent activation of downstream antioxidant genes. Given the association between the Keap1-Nrf2 signaling pathway and various diseases such as cancer, neurodegenerative disorders, and diabetes, comprehending the post-translational modification of Keap1 not only deepens our understanding of Nrf2 signaling regulation but also contributes to the identification of novel drug targets and biomarkers. Consequently, this knowledge holds immense importance in the prevention and treatment of diseases induced by oxidative stress.https://www.frontiersin.org/articles/10.3389/fcell.2023.1332049/fullKeap1Nrf2post-translational modificationoxidative stressbiomarker |
| spellingShingle | Yunjia Song Ying Qu Caiyun Mao Rong Zhang Deyou Jiang Xutao Sun Post-translational modifications of Keap1: the state of the art Frontiers in Cell and Developmental Biology Keap1 Nrf2 post-translational modification oxidative stress biomarker |
| title | Post-translational modifications of Keap1: the state of the art |
| title_full | Post-translational modifications of Keap1: the state of the art |
| title_fullStr | Post-translational modifications of Keap1: the state of the art |
| title_full_unstemmed | Post-translational modifications of Keap1: the state of the art |
| title_short | Post-translational modifications of Keap1: the state of the art |
| title_sort | post translational modifications of keap1 the state of the art |
| topic | Keap1 Nrf2 post-translational modification oxidative stress biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1332049/full |
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