Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults
Abstract Background Cardio-cerebrovascular diseases constitute a major global public health burden. Volatile organic compounds (VOCs) exposure has become progressively severe, endangering human health and becoming one of the main concerns in environmental pollution. The associations of VOCs exposure...
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BMC
2024-02-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-024-18115-7 |
| _version_ | 1827325872935272448 |
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| author | Li Jing Tiancong Chen Zhiyong Yang Weiwei Dong |
| author_facet | Li Jing Tiancong Chen Zhiyong Yang Weiwei Dong |
| author_sort | Li Jing |
| collection | DOAJ |
| description | Abstract Background Cardio-cerebrovascular diseases constitute a major global public health burden. Volatile organic compounds (VOCs) exposure has become progressively severe, endangering human health and becoming one of the main concerns in environmental pollution. The associations of VOCs exposure with nonfatal cardio-cerebrovascular events have not been identified in observational study with a large sample size, so we aim to examine the association in US adult population. Methods Adults aged > 18 years with complete data regarding selected blood levels of VOCs (including benzene, ethylbenzene, o-xylene, and m-/p-xylene) and nonfatal cardio-cerebrovascular events were included in the analysis (n = 3,968, National Health and Nutrition Examination Survey, NHANES, 2013–2018 survey cycle). Participants were classified into low- and high-exposure based on whether above selected VOCs low limit detect concentration or median value. Weighted multivariate logistic analyses and subgroup analyses were used to detect the association between selected VOCs exposure and nonfatal cardio-cerebrovascular events in US adults. Results Weighted multivariate logistic analyses showed that the high-VOCs exposure group had an increased risk of nonfatal cardio-cerebrovascular events compared with the low-VOCs exposure group; the adjusted odds ratios (OR) and 95% confidence intervals (CI) of nonfatal cardio-cerebrovascular events for the high-VOCs exposure group were 1.41 (0.91, 2.19), 1.37 (0.96, 1.95), 1.32 (0.96, 1.82), and 1.17 (0.82, 1.67) for benzene, ethylbenzene, o-xylene, and m-/p-xylene, respectively, which was not significant assuming statistical significance at a 0.05 significance level (95% CI) for a two-tailed test. Lastly, we found high-VOCs exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in both daily smokers an non-daily smokers (p-interaction > 0.01), but the association was not statistically significant in non-daily smokers. Conclusions This study found that VOCs (benzene, ethylbenzene, o-xylene, and m-/p-xylene) exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in US adults, and the results need to be confirmed by larger cohort studies. |
| first_indexed | 2024-03-07T14:35:35Z |
| format | Article |
| id | doaj.art-1a9a927baf044244913d29b74e44908c |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-07T14:35:35Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-1a9a927baf044244913d29b74e44908c2024-03-05T20:37:49ZengBMCBMC Public Health1471-24582024-02-012411910.1186/s12889-024-18115-7Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adultsLi Jing0Tiancong Chen1Zhiyong Yang2Weiwei Dong3Department of Nursing, Shengjing Hospital of China Medical UniversityDepartment of Nursing, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, Shengjing Hospital of China Medical UniversityDepartment of Neurosurgery, Shengjing Hospital of China Medical UniversityAbstract Background Cardio-cerebrovascular diseases constitute a major global public health burden. Volatile organic compounds (VOCs) exposure has become progressively severe, endangering human health and becoming one of the main concerns in environmental pollution. The associations of VOCs exposure with nonfatal cardio-cerebrovascular events have not been identified in observational study with a large sample size, so we aim to examine the association in US adult population. Methods Adults aged > 18 years with complete data regarding selected blood levels of VOCs (including benzene, ethylbenzene, o-xylene, and m-/p-xylene) and nonfatal cardio-cerebrovascular events were included in the analysis (n = 3,968, National Health and Nutrition Examination Survey, NHANES, 2013–2018 survey cycle). Participants were classified into low- and high-exposure based on whether above selected VOCs low limit detect concentration or median value. Weighted multivariate logistic analyses and subgroup analyses were used to detect the association between selected VOCs exposure and nonfatal cardio-cerebrovascular events in US adults. Results Weighted multivariate logistic analyses showed that the high-VOCs exposure group had an increased risk of nonfatal cardio-cerebrovascular events compared with the low-VOCs exposure group; the adjusted odds ratios (OR) and 95% confidence intervals (CI) of nonfatal cardio-cerebrovascular events for the high-VOCs exposure group were 1.41 (0.91, 2.19), 1.37 (0.96, 1.95), 1.32 (0.96, 1.82), and 1.17 (0.82, 1.67) for benzene, ethylbenzene, o-xylene, and m-/p-xylene, respectively, which was not significant assuming statistical significance at a 0.05 significance level (95% CI) for a two-tailed test. Lastly, we found high-VOCs exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in both daily smokers an non-daily smokers (p-interaction > 0.01), but the association was not statistically significant in non-daily smokers. Conclusions This study found that VOCs (benzene, ethylbenzene, o-xylene, and m-/p-xylene) exposure was associated with increased incidence of nonfatal cardio-cerebrovascular events in US adults, and the results need to be confirmed by larger cohort studies.https://doi.org/10.1186/s12889-024-18115-7VOCsMyocardial infarctionStrokeNHANESCross-sectional study |
| spellingShingle | Li Jing Tiancong Chen Zhiyong Yang Weiwei Dong Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults BMC Public Health VOCs Myocardial infarction Stroke NHANES Cross-sectional study |
| title | Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults |
| title_full | Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults |
| title_fullStr | Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults |
| title_full_unstemmed | Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults |
| title_short | Association of the blood levels of specific volatile organic compounds with nonfatal cardio-cerebrovascular events in US adults |
| title_sort | association of the blood levels of specific volatile organic compounds with nonfatal cardio cerebrovascular events in us adults |
| topic | VOCs Myocardial infarction Stroke NHANES Cross-sectional study |
| url | https://doi.org/10.1186/s12889-024-18115-7 |
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