Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog
A 13-year-old castrated male Toy Poodle presented with an acute vestibular disorder. Magnetic resonance imaging and computed tomography revealed a large oval space-occupying mass with skull destruction located from the subcutaneous tissue to the posterior fossa region. Histopathologically, the mass...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.977099/full |
| _version_ | 1818469663765430272 |
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| author | Kyosuke Hidari Yuya Nakamoto Yuya Nakamoto Keiichi Sakurai Yoko Sakurai Kazumi Nibe Miwa Nakamoto |
| author_facet | Kyosuke Hidari Yuya Nakamoto Yuya Nakamoto Keiichi Sakurai Yoko Sakurai Kazumi Nibe Miwa Nakamoto |
| author_sort | Kyosuke Hidari |
| collection | DOAJ |
| description | A 13-year-old castrated male Toy Poodle presented with an acute vestibular disorder. Magnetic resonance imaging and computed tomography revealed a large oval space-occupying mass with skull destruction located from the subcutaneous tissue to the posterior fossa region. Histopathologically, the mass was a bundled growth of spindle-shaped mesenchymal tumor cells between the myofibrillar and collagen bundles. The cells were moderately irregular in size and had eosinophilic stained cytoplasm. The cells were highly atypical and had rare mitotic figures. Neoplastic cells were immunoreactive for S100, GFAP, Olig-2, SOX10 and immunonegative for NF, E-cadherin, and Claudin-1. Collective findings were presumptive with a diagnosis of malignant peripheral nerve sheath tumor. |
| first_indexed | 2024-04-13T21:27:30Z |
| format | Article |
| id | doaj.art-1a9ec012b5614325b03cacba19691cbf |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-13T21:27:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-1a9ec012b5614325b03cacba19691cbf2022-12-22T02:29:16ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-11-01910.3389/fvets.2022.977099977099Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dogKyosuke Hidari0Yuya Nakamoto1Yuya Nakamoto2Keiichi Sakurai3Yoko Sakurai4Kazumi Nibe5Miwa Nakamoto6Neuro Vets Animal Neurology Clinic, Kyoto, JapanNeuro Vets Animal Neurology Clinic, Kyoto, JapanVeterinary Medical Center, Osaka Metropolitan University, Osaka, JapanSakura Animal Hospital, Kyoto, JapanSakura Animal Hospital, Kyoto, JapanFUJIFUILM VET Systems Co., Ltd., Tokyo, JapanNeuro Vets Animal Neurology Clinic, Kyoto, JapanA 13-year-old castrated male Toy Poodle presented with an acute vestibular disorder. Magnetic resonance imaging and computed tomography revealed a large oval space-occupying mass with skull destruction located from the subcutaneous tissue to the posterior fossa region. Histopathologically, the mass was a bundled growth of spindle-shaped mesenchymal tumor cells between the myofibrillar and collagen bundles. The cells were moderately irregular in size and had eosinophilic stained cytoplasm. The cells were highly atypical and had rare mitotic figures. Neoplastic cells were immunoreactive for S100, GFAP, Olig-2, SOX10 and immunonegative for NF, E-cadherin, and Claudin-1. Collective findings were presumptive with a diagnosis of malignant peripheral nerve sheath tumor.https://www.frontiersin.org/articles/10.3389/fvets.2022.977099/fullperipheral nerve sheath tumorextracranial tumorintracranial invasionmalignant lesionosteolysisoccipital region |
| spellingShingle | Kyosuke Hidari Yuya Nakamoto Yuya Nakamoto Keiichi Sakurai Yoko Sakurai Kazumi Nibe Miwa Nakamoto Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog Frontiers in Veterinary Science peripheral nerve sheath tumor extracranial tumor intracranial invasion malignant lesion osteolysis occipital region |
| title | Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| title_full | Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| title_fullStr | Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| title_full_unstemmed | Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| title_short | Case report: Presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| title_sort | case report presumptive subcutaneous malignant peripheral nerve sheath tumor with intracranial invasion and osteolysis in the posterior fossa of a dog |
| topic | peripheral nerve sheath tumor extracranial tumor intracranial invasion malignant lesion osteolysis occipital region |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.977099/full |
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