Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
Yaling Zhang,1,2 Kaiyun Li,1 Chao Zhang,1 Hui Liao,3 Rongshan Li1 1Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), Taiyuan, People’s Republic of China; 2Department of Nephrology, Taiyuan Central Hospital, Taiyuan, People’s Republic of Chin...
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Dove Medical Press
2023-07-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/research-progress-of-cordyceps-sinensis-and-its-fermented-mycelium-pro-peer-reviewed-fulltext-article-JIR |
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| author | Zhang Y Li K Zhang C Liao H Li R |
| author_facet | Zhang Y Li K Zhang C Liao H Li R |
| author_sort | Zhang Y |
| collection | DOAJ |
| description | Yaling Zhang,1,2 Kaiyun Li,1 Chao Zhang,1 Hui Liao,3 Rongshan Li1 1Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), Taiyuan, People’s Republic of China; 2Department of Nephrology, Taiyuan Central Hospital, Taiyuan, People’s Republic of China; 3Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), Taiyuan, People’s Republic of ChinaCorrespondence: Rongshan Li, Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), No. 29 Shuangtasi Street, Taiyuan, Shanxi Province, 030012, People’s Republic of China, Email rongshanli13@163.comAbstract: Renal fibrosis is a hallmark and common outcome of various chronic kidney diseases (CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix (ECM) in the kidney. Epithelial-to-mesenchymal transition (EMT) has been shown to be an important mechanism involved in renal fibrosis. Cordyceps sinensis, a traditional Chinese medicine, has long been used for the treatment of renal fibrosis. As research on the mycelium of C. sinensis progressed, a variety of medicines developed from fermented mycelium were used to treat CKD. However, their efficacies and mechanisms have not been fully summarized. In this review, five medicines developed from fermented mycelium of C. sinensis are presented. The pharmacodynamic effects of C. sinensis on different animal models of renal fibrosis are summarized. The in vitro studies and related mechanisms of C. sinensis on renal cells are detailed. Finally, the application and efficacy of these five commercial medicines that meet national standards in different types of CKD are summarized. From this review, it can be concluded that C. sinensis can alleviate various causes of renal fibrosis to some extent, and its mechanism is related to TGF-β 1 dependent signaling, inhibition of inflammation, and improvement of renal function. Further research on rigorously designed, large-sample, clinically randomized controlled trial studies and detailed mechanisms should be conducted.Keywords: renal fibrosis, Cordyceps sinensis, fermented mycelium products, epithelial-to-mesenchymal transition |
| first_indexed | 2024-03-13T00:36:29Z |
| format | Article |
| id | doaj.art-1a9ef4ad3dd34979a45b420db378d782 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-13T00:36:29Z |
| publishDate | 2023-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-1a9ef4ad3dd34979a45b420db378d7822023-07-09T19:03:31ZengDove Medical PressJournal of Inflammation Research1178-70312023-07-01Volume 162817283084990Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal TransitionZhang YLi KZhang CLiao HLi RYaling Zhang,1,2 Kaiyun Li,1 Chao Zhang,1 Hui Liao,3 Rongshan Li1 1Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), Taiyuan, People’s Republic of China; 2Department of Nephrology, Taiyuan Central Hospital, Taiyuan, People’s Republic of China; 3Department of Pharmacy, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), Taiyuan, People’s Republic of ChinaCorrespondence: Rongshan Li, Department of Nephrology, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People’s Hospital), No. 29 Shuangtasi Street, Taiyuan, Shanxi Province, 030012, People’s Republic of China, Email rongshanli13@163.comAbstract: Renal fibrosis is a hallmark and common outcome of various chronic kidney diseases (CKDs) and manifests pathologically as accumulation and deposition of extracellular matrix (ECM) in the kidney. Epithelial-to-mesenchymal transition (EMT) has been shown to be an important mechanism involved in renal fibrosis. Cordyceps sinensis, a traditional Chinese medicine, has long been used for the treatment of renal fibrosis. As research on the mycelium of C. sinensis progressed, a variety of medicines developed from fermented mycelium were used to treat CKD. However, their efficacies and mechanisms have not been fully summarized. In this review, five medicines developed from fermented mycelium of C. sinensis are presented. The pharmacodynamic effects of C. sinensis on different animal models of renal fibrosis are summarized. The in vitro studies and related mechanisms of C. sinensis on renal cells are detailed. Finally, the application and efficacy of these five commercial medicines that meet national standards in different types of CKD are summarized. From this review, it can be concluded that C. sinensis can alleviate various causes of renal fibrosis to some extent, and its mechanism is related to TGF-β 1 dependent signaling, inhibition of inflammation, and improvement of renal function. Further research on rigorously designed, large-sample, clinically randomized controlled trial studies and detailed mechanisms should be conducted.Keywords: renal fibrosis, Cordyceps sinensis, fermented mycelium products, epithelial-to-mesenchymal transitionhttps://www.dovepress.com/research-progress-of-cordyceps-sinensis-and-its-fermented-mycelium-pro-peer-reviewed-fulltext-article-JIRrenal fibrosiscordyceps sinensisfermented mycelium productsepithelial-to-mesenchymal transition |
| spellingShingle | Zhang Y Li K Zhang C Liao H Li R Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition Journal of Inflammation Research renal fibrosis cordyceps sinensis fermented mycelium products epithelial-to-mesenchymal transition |
| title | Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition |
| title_full | Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition |
| title_fullStr | Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition |
| title_full_unstemmed | Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition |
| title_short | Research Progress of Cordyceps sinensis and Its Fermented Mycelium Products on Ameliorating Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition |
| title_sort | research progress of cordyceps sinensis and its fermented mycelium products on ameliorating renal fibrosis by reducing epithelial to mesenchymal transition |
| topic | renal fibrosis cordyceps sinensis fermented mycelium products epithelial-to-mesenchymal transition |
| url | https://www.dovepress.com/research-progress-of-cordyceps-sinensis-and-its-fermented-mycelium-pro-peer-reviewed-fulltext-article-JIR |
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