Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion

Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion

Abstract Background Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease and associated with poor outcome after myocardial infarction (MI). In T2DM, cardiac metabolic flexibility, i.e. the switch between carbohydrates and lipids as energy source, is disturbed. The RabGTP...

Full description

Bibliographic Details
Main Authors: C. Binsch, D. M. Barbosa, G. Hansen-Dille, M. Hubert, S. M. Hodge, M. Kolasa, K. Jeruschke, J. Weiß, C. Springer, S. Gorressen, J. W. Fischer, M. Lienhard, R. Herwig, S. Börno, B. Timmermann, A. L. Cremer, H. Backes, A. Chadt, H. Al-Hasani
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Cardiovascular Diabetology
Subjects:
Myocardial infarction
Ischemia/reperfusion
TBC1D4
Metabolic flexibility
Online Access:https://doi.org/10.1186/s12933-023-01746-2

Similar Items

Similar Items