Endocrine issues and premenopausal breast cancer
There is an alarming increasing incidence of PBC (premenopausal breast cancer) in countries with high income due to, on one hand, more accessible screening tools and, on the other hand, potential implications of daily lifestyle habits and endocrine disruptors of modern society on terms of facilitati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2021-12-01
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| Series: | Romanian Journal of Medical Practice |
| Subjects: | |
| Online Access: | https://rjmp.com.ro/articles/2021.4/RJMP_2021_4_Art-25.pdf |
| _version_ | 1797293768667299840 |
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| author | Mara Carsote Diana Elena Rentea Aida Petca Stefania Zugravu Claudia Mehedintu Florica Sandru Anda Dumitrascu Mihai Cristian Dumitrascu |
| author_facet | Mara Carsote Diana Elena Rentea Aida Petca Stefania Zugravu Claudia Mehedintu Florica Sandru Anda Dumitrascu Mihai Cristian Dumitrascu |
| author_sort | Mara Carsote |
| collection | DOAJ |
| description | There is an alarming increasing incidence of PBC (premenopausal breast cancer) in countries with high income due to, on one hand, more accessible screening tools and, on the other hand, potential implications of daily lifestyle habits and endocrine disruptors of modern society on terms of facilitating tumor growth. A
more severe prognostic is found in females younger than 40 years old at first detection, with advanced disease at diagnostic, and those with tumors displaying specific immunohistochemistry configuration (and associated gene profile) like ER (estrogen receptor) positive or HEGFR2 (human epidermal growth factor receptor) negative. Recently, particular aspects are reported in terms of PBC therapy: the switch from offering aromatase inhibitors/tamoxifen only in post-menopausal females was done to premenopausal subjects in addition to medication that offers ovarian function suppression (OFS) – as an alternative to
classical oophorectomy - for 5 years up to 10 years extension depending on protocol and patient’ age at first diagnostic. The main endocrine considerations concerning PBC are: OFS and/or chemotherapy or oophorectomy causing prompt hypogonadism, bone status anomalies due to estrogens deficiency, potential endocrine tumors that are prone to be linked (for instance, a higher risk of cancer in acromegalic patients etc.), cardio-metabolic elements as facilitators of early tumorigenesis, fertility issues on PBC survivals etc. The purpose of the present paper is to introduce several key messages that relate to endocrine implications of PBC starting from a case. |
| first_indexed | 2024-03-07T21:20:39Z |
| format | Article |
| id | doaj.art-1aa05880ae674fe8815b0a756b5e59b0 |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-03-07T21:20:39Z |
| publishDate | 2021-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-1aa05880ae674fe8815b0a756b5e59b02024-02-27T13:03:36ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082021-12-0116453353910.37897/RJMP.2021.4.25Endocrine issues and premenopausal breast cancerMara Carsote0Diana Elena Rentea1Aida Petca2Stefania Zugravu3Claudia Mehedintu4Florica Sandru5Anda Dumitrascu6Mihai Cristian Dumitrascu7“C.I. Parhon“ National Institute of Endocrinology, Bucharest, Romania; “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania“C.I. Parhon“ National Institute of Endocrinology, Bucharest, Romania “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; Elias Emergency Hospital, Bucharest, Romania“C.I. Parhon“ National Institute of Endocrinology, Bucharest, Romania “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; “Nicolae Malaxa” Clinical Hospital, Bucharest, Romania“Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; Elias Emergency Hospital, Bucharest, Romania“C.I. Parhon“ National Institute of Endocrinology, Bucharest, Romania “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania; University Emergency Hospital, Bucharest, RomaniaThere is an alarming increasing incidence of PBC (premenopausal breast cancer) in countries with high income due to, on one hand, more accessible screening tools and, on the other hand, potential implications of daily lifestyle habits and endocrine disruptors of modern society on terms of facilitating tumor growth. A more severe prognostic is found in females younger than 40 years old at first detection, with advanced disease at diagnostic, and those with tumors displaying specific immunohistochemistry configuration (and associated gene profile) like ER (estrogen receptor) positive or HEGFR2 (human epidermal growth factor receptor) negative. Recently, particular aspects are reported in terms of PBC therapy: the switch from offering aromatase inhibitors/tamoxifen only in post-menopausal females was done to premenopausal subjects in addition to medication that offers ovarian function suppression (OFS) – as an alternative to classical oophorectomy - for 5 years up to 10 years extension depending on protocol and patient’ age at first diagnostic. The main endocrine considerations concerning PBC are: OFS and/or chemotherapy or oophorectomy causing prompt hypogonadism, bone status anomalies due to estrogens deficiency, potential endocrine tumors that are prone to be linked (for instance, a higher risk of cancer in acromegalic patients etc.), cardio-metabolic elements as facilitators of early tumorigenesis, fertility issues on PBC survivals etc. The purpose of the present paper is to introduce several key messages that relate to endocrine implications of PBC starting from a case.https://rjmp.com.ro/articles/2021.4/RJMP_2021_4_Art-25.pdfbreast cancermenopausehypogonadismosteoporosisacromegalyadrenal hyperplasiaboneovarian suppressionovarian function suppressiontamoxifenaromatase inhibitorgoserelinincientaloma |
| spellingShingle | Mara Carsote Diana Elena Rentea Aida Petca Stefania Zugravu Claudia Mehedintu Florica Sandru Anda Dumitrascu Mihai Cristian Dumitrascu Endocrine issues and premenopausal breast cancer Romanian Journal of Medical Practice breast cancer menopause hypogonadism osteoporosis acromegaly adrenal hyperplasia bone ovarian suppression ovarian function suppression tamoxifen aromatase inhibitor goserelin incientaloma |
| title | Endocrine issues and premenopausal breast cancer |
| title_full | Endocrine issues and premenopausal breast cancer |
| title_fullStr | Endocrine issues and premenopausal breast cancer |
| title_full_unstemmed | Endocrine issues and premenopausal breast cancer |
| title_short | Endocrine issues and premenopausal breast cancer |
| title_sort | endocrine issues and premenopausal breast cancer |
| topic | breast cancer menopause hypogonadism osteoporosis acromegaly adrenal hyperplasia bone ovarian suppression ovarian function suppression tamoxifen aromatase inhibitor goserelin incientaloma |
| url | https://rjmp.com.ro/articles/2021.4/RJMP_2021_4_Art-25.pdf |
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