Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial
Background: Electroconvulsive Therapy (ECT) is a successful treatment option for various psychiatric disorders. It is performed under general anesthesia where succinylcholine is the preferred muscle relaxant in this process. However its several contraindications and potential adverse effects, and th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2022-07-01
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| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/article-1-547-en.html |
| _version_ | 1818043681826930688 |
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| author | Abbas Sedighinejad Hossein Khoshrang Soheil Soltanipour Seyed Mahmood Rezvani Robabeh Soleimani Mohammad Haghighi Siamak Rimaz Gelareh Biazar |
| author_facet | Abbas Sedighinejad Hossein Khoshrang Soheil Soltanipour Seyed Mahmood Rezvani Robabeh Soleimani Mohammad Haghighi Siamak Rimaz Gelareh Biazar |
| author_sort | Abbas Sedighinejad |
| collection | DOAJ |
| description | Background: Electroconvulsive Therapy (ECT) is a successful treatment option for various psychiatric disorders. It is performed under general anesthesia where succinylcholine is the preferred muscle relaxant in this process. However its several contraindications and potential adverse effects, and the fact that it is not always available should be considered. Therefore, finding an effective and safe alternative is crucial.
Objectives: This study aims to assess the safety and efficacy of atracurium in ECT.
Materials & Methods: This single-blind clinical trial was conducted at Shafa hospital affiliated to Guilan University of Medical Sciences from November 2020 to April 2021. Participants were 67 eligible patients with ECT, randomly assigned into two groups receiving succinylcholine (0.5 mg/ kg), and atracurium (0.2 mg/kg). Seizure duration, hemodynamic parameters, the time to return to spontaneous breathing, and recovery time were assessed and compared between the two groups.
Results: Seizure duration was longer in the succinylcholine group (P=0.071), while the time to return to spontaneous breathing (P=0.0001) and the recovery time (P=0.0001) were significantly longer in the atracurium group. The trend of changes in the Mean Arterial Pressure (MAP) and Heart Rate (HR) were significant over time; however, the difference between the two groups was significant only in HR one minute after the seizure induction (P=0.001). None of patients was reported serious adverse effects.
Conclusion: When succinylcholine can't be used, atracurium can be a safe alternative in the ECT process. |
| first_indexed | 2024-12-10T09:06:05Z |
| format | Article |
| id | doaj.art-1aa145faa9f242c9b4609a699da7e29c |
| institution | Directory Open Access Journal |
| issn | 2423-4818 |
| language | English |
| last_indexed | 2024-12-10T09:06:05Z |
| publishDate | 2022-07-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-1aa145faa9f242c9b4609a699da7e29c2022-12-22T01:55:08ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182022-07-0183163170Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical TrialAbbas Sedighinejad0Hossein Khoshrang1Soheil Soltanipour2Seyed Mahmood Rezvani3Robabeh Soleimani4Mohammad Haghighi5Siamak Rimaz6Gelareh Biazar7 Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Student Research Committee, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Department of Psychiatry, Kavosh behavioral, cognitive and addiction research center, Shafa hospital, Guilan University of Medical Sciences, Rasht, Iran Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Anesthesiology Research Center, Department of Anesthesiology, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran Background: Electroconvulsive Therapy (ECT) is a successful treatment option for various psychiatric disorders. It is performed under general anesthesia where succinylcholine is the preferred muscle relaxant in this process. However its several contraindications and potential adverse effects, and the fact that it is not always available should be considered. Therefore, finding an effective and safe alternative is crucial. Objectives: This study aims to assess the safety and efficacy of atracurium in ECT. Materials & Methods: This single-blind clinical trial was conducted at Shafa hospital affiliated to Guilan University of Medical Sciences from November 2020 to April 2021. Participants were 67 eligible patients with ECT, randomly assigned into two groups receiving succinylcholine (0.5 mg/ kg), and atracurium (0.2 mg/kg). Seizure duration, hemodynamic parameters, the time to return to spontaneous breathing, and recovery time were assessed and compared between the two groups. Results: Seizure duration was longer in the succinylcholine group (P=0.071), while the time to return to spontaneous breathing (P=0.0001) and the recovery time (P=0.0001) were significantly longer in the atracurium group. The trend of changes in the Mean Arterial Pressure (MAP) and Heart Rate (HR) were significant over time; however, the difference between the two groups was significant only in HR one minute after the seizure induction (P=0.001). None of patients was reported serious adverse effects. Conclusion: When succinylcholine can't be used, atracurium can be a safe alternative in the ECT process.http://cjns.gums.ac.ir/article-1-547-en.htmlatracuriumelectroconvulsive therapysuccinylcholine |
| spellingShingle | Abbas Sedighinejad Hossein Khoshrang Soheil Soltanipour Seyed Mahmood Rezvani Robabeh Soleimani Mohammad Haghighi Siamak Rimaz Gelareh Biazar Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial Caspian Journal of Neurological Sciences atracurium electroconvulsive therapy succinylcholine |
| title | Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial |
| title_full | Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial |
| title_fullStr | Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial |
| title_full_unstemmed | Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial |
| title_short | Atracurium as an Alternative to Succinylcholine in Electroconvulsive Therapy: A Randomized Clinical Trial |
| title_sort | atracurium as an alternative to succinylcholine in electroconvulsive therapy a randomized clinical trial |
| topic | atracurium electroconvulsive therapy succinylcholine |
| url | http://cjns.gums.ac.ir/article-1-547-en.html |
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