Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes
We have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2011-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641102289S.pdf |
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| author | Saksida Tamara Miljković D. Dekanski Dragana Stojanović Ivana Stošić-Grujičić Stanislava |
| author_facet | Saksida Tamara Miljković D. Dekanski Dragana Stojanović Ivana Stošić-Grujičić Stanislava |
| author_sort | Saksida Tamara |
| collection | DOAJ |
| description | We have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack. |
| first_indexed | 2024-04-12T21:52:37Z |
| format | Article |
| id | doaj.art-1aa24ffb3d1e40209f975001a88f5b09 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-04-12T21:52:37Z |
| publishDate | 2011-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-1aa24ffb3d1e40209f975001a88f5b092022-12-22T03:15:25ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642011-01-0163228929710.2298/ABS1102289SDry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodesSaksida TamaraMiljković D.Dekanski DraganaStojanović IvanaStošić-Grujičić StanislavaWe have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack.http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641102289S.pdfAutoimmune diabetesstreptozotocinolive leaf extractcytokineinflammationC57BL/6 mice |
| spellingShingle | Saksida Tamara Miljković D. Dekanski Dragana Stojanović Ivana Stošić-Grujičić Stanislava Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes Archives of Biological Sciences Autoimmune diabetes streptozotocin olive leaf extract cytokine inflammation C57BL/6 mice |
| title | Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| title_full | Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| title_fullStr | Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| title_full_unstemmed | Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| title_short | Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| title_sort | dry olive leaf extract dole down regulates the progression of experimental immune mediated diabetes by modulation of cytokine profile in the draining lymph nodes |
| topic | Autoimmune diabetes streptozotocin olive leaf extract cytokine inflammation C57BL/6 mice |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641102289S.pdf |
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