In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-amyloid immunotherapy

In vivo detection of amyloid plaques by gadolinium-stained MRI can be used to demonstrate the efficacy of an anti-amyloid immunotherapy

Extracellular deposition of β amyloid plaques is an early event associated to Alzheimer's disease. Here we have used in vivo gadolinium-stained high resolution (29*29*117µm3) MRI to follow-up in a longitudinal way individual amyloid plaques in APP/PS1 mice and evaluate the efficacy of a new imm...

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Bibliographic Details
Main Authors: Mathieu D. Santin, Michel E. Vandenberghe, Anne-Sophie eHerard, Laurent ePradier, Caroline eCohen, Thomas eDebeir, Thierry eDelzescaux, Thomas eRooney, Marc eDhenain
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
Amyloid
Gadolinium
Immunotherapy
Alzheimer's disease
MRI imaging
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00055/full

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