Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020
Abstract Introduction Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia. Methods We analyzed the associa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12293 |
| _version_ | 1797949037571211264 |
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| author | Christian Schnier Janet Janbek Richard Lathe Jürgen Haas |
| author_facet | Christian Schnier Janet Janbek Richard Lathe Jürgen Haas |
| author_sort | Christian Schnier |
| collection | DOAJ |
| description | Abstract Introduction Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia. Methods We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data. Results Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all‐cause mortality. Discussion Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy. |
| first_indexed | 2024-04-10T21:53:00Z |
| format | Article |
| id | doaj.art-1aa49262cf1d481782e39b03e2c220a8 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:53:00Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-1aa49262cf1d481782e39b03e2c220a82023-01-18T11:41:03ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12293Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020Christian Schnier0Janet Janbek1Richard Lathe2Jürgen Haas3Division of Infection Medicine University of Edinburgh Medical School Edinburgh UKDanish Dementia Research Centre Rigshospitalet University of Copenhagen Copenhagen DenmarkDivision of Infection Medicine University of Edinburgh Medical School Edinburgh UKDivision of Infection Medicine University of Edinburgh Medical School Edinburgh UKAbstract Introduction Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia. Methods We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data. Results Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all‐cause mortality. Discussion Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.https://doi.org/10.1002/trc2.12293Alzheimer's diseaseshinglesvaccinevascular dementia |
| spellingShingle | Christian Schnier Janet Janbek Richard Lathe Jürgen Haas Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease shingles vaccine vascular dementia |
| title | Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 |
| title_full | Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 |
| title_fullStr | Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 |
| title_full_unstemmed | Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 |
| title_short | Reduced dementia incidence after varicella zoster vaccination in Wales 2013–2020 |
| title_sort | reduced dementia incidence after varicella zoster vaccination in wales 2013 2020 |
| topic | Alzheimer's disease shingles vaccine vascular dementia |
| url | https://doi.org/10.1002/trc2.12293 |
| work_keys_str_mv | AT christianschnier reduceddementiaincidenceaftervaricellazostervaccinationinwales20132020 AT janetjanbek reduceddementiaincidenceaftervaricellazostervaccinationinwales20132020 AT richardlathe reduceddementiaincidenceaftervaricellazostervaccinationinwales20132020 AT jurgenhaas reduceddementiaincidenceaftervaricellazostervaccinationinwales20132020 |