Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue
ObjectivesOur goal was to analyze the possibility of using metabolic tumor volume (MTV) to predict occult cervical metastasis and survival in cT1-2N0 squamous cell carcinoma (SCC) of the tongue.MethodsData on the primary tumor MTV and cervical node status as determined by the maximum standardized up...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.542530/full |
| _version_ | 1819171545342279680 |
|---|---|
| author | Lijie Yang Fei Liu Yao Wu Qigen Fang Xiaojun Zhang Wei Du Xu Zhang Defeng Chen Ruihua Luo |
| author_facet | Lijie Yang Fei Liu Yao Wu Qigen Fang Xiaojun Zhang Wei Du Xu Zhang Defeng Chen Ruihua Luo |
| author_sort | Lijie Yang |
| collection | DOAJ |
| description | ObjectivesOur goal was to analyze the possibility of using metabolic tumor volume (MTV) to predict occult cervical metastasis and survival in cT1-2N0 squamous cell carcinoma (SCC) of the tongue.MethodsData on the primary tumor MTV and cervical node status as determined by the maximum standardized uptake value were retrieved. The sensitivity and specificity in predicting occult metastasis were calculated with a fourfold table. Associations between occult metastasis and clinicopathological variables were evaluated by univariate and multivariate analyses. The main study endpoints were locoregional control (LRC) and disease-specific survival (DSS).ResultsA total of 24 (20.3%) of 118 patients had occult metastasis. An MTV cutoff value of 4.3 cm3 showed a sensitivity of 50.0% and a specificity of 76.6% in predicting occult metastasis. The sensitivity and specificity of PET-CT in predicting occult metastasis in cT1 tumors were 66.6 and 89.8%, respectively, with values of 83.3 and 67.3%, respectively, when combined with the MTV. The sensitivity and specificity of PET-CT in predicting occult metastasis in cT2 tumors were 72.2 and 82.2%, respectively, with values of 88.9 and 57.8%, respectively, when combined with the MTV. Patients with MTV ≥4.3 cm3 had a higher occult metastasis rate than patients with MTV <4.3 cm3. The 5-year LRC and DSS rates were 86 and 94%, respectively, in patients with MTV <4.3 cm3 and 54 and 72%, respectively, in patients with MTV ≥4.3 cm3. Both differences were found to be significant in univariate and multivariate analyses.ConclusionsMTV ≥4.3 cm3 was associated with an increased probability of occult metastasis and lower LRC and DSS rates in early-stage SCC of the tongue. |
| first_indexed | 2024-12-22T19:52:59Z |
| format | Article |
| id | doaj.art-1aa4b0c44d5a4740b8faeb93e4f8219d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T19:52:59Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1aa4b0c44d5a4740b8faeb93e4f8219d2022-12-21T18:14:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.542530542530Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the TongueLijie Yang0Fei Liu1Yao Wu2Qigen Fang3Xiaojun Zhang4Wei Du5Xu Zhang6Defeng Chen7Ruihua Luo8Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Head Neck and Thyroid, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, ChinaObjectivesOur goal was to analyze the possibility of using metabolic tumor volume (MTV) to predict occult cervical metastasis and survival in cT1-2N0 squamous cell carcinoma (SCC) of the tongue.MethodsData on the primary tumor MTV and cervical node status as determined by the maximum standardized uptake value were retrieved. The sensitivity and specificity in predicting occult metastasis were calculated with a fourfold table. Associations between occult metastasis and clinicopathological variables were evaluated by univariate and multivariate analyses. The main study endpoints were locoregional control (LRC) and disease-specific survival (DSS).ResultsA total of 24 (20.3%) of 118 patients had occult metastasis. An MTV cutoff value of 4.3 cm3 showed a sensitivity of 50.0% and a specificity of 76.6% in predicting occult metastasis. The sensitivity and specificity of PET-CT in predicting occult metastasis in cT1 tumors were 66.6 and 89.8%, respectively, with values of 83.3 and 67.3%, respectively, when combined with the MTV. The sensitivity and specificity of PET-CT in predicting occult metastasis in cT2 tumors were 72.2 and 82.2%, respectively, with values of 88.9 and 57.8%, respectively, when combined with the MTV. Patients with MTV ≥4.3 cm3 had a higher occult metastasis rate than patients with MTV <4.3 cm3. The 5-year LRC and DSS rates were 86 and 94%, respectively, in patients with MTV <4.3 cm3 and 54 and 72%, respectively, in patients with MTV ≥4.3 cm3. Both differences were found to be significant in univariate and multivariate analyses.ConclusionsMTV ≥4.3 cm3 was associated with an increased probability of occult metastasis and lower LRC and DSS rates in early-stage SCC of the tongue.https://www.frontiersin.org/articles/10.3389/fonc.2020.542530/fullPET-CTmetabolic tumor volumeearly-stage squamous cell carcinoma of the tongueoral squamous cell carcinomatongue squamous cell carcinoma |
| spellingShingle | Lijie Yang Fei Liu Yao Wu Qigen Fang Xiaojun Zhang Wei Du Xu Zhang Defeng Chen Ruihua Luo Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue Frontiers in Oncology PET-CT metabolic tumor volume early-stage squamous cell carcinoma of the tongue oral squamous cell carcinoma tongue squamous cell carcinoma |
| title | Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue |
| title_full | Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue |
| title_fullStr | Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue |
| title_full_unstemmed | Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue |
| title_short | Predictive Value of Occult Metastasis and Survival Significance of Metabolic Tumor Volume Determined by PET-CT in cT1-2N0 Squamous Cell Carcinoma of the Tongue |
| title_sort | predictive value of occult metastasis and survival significance of metabolic tumor volume determined by pet ct in ct1 2n0 squamous cell carcinoma of the tongue |
| topic | PET-CT metabolic tumor volume early-stage squamous cell carcinoma of the tongue oral squamous cell carcinoma tongue squamous cell carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.542530/full |
| work_keys_str_mv | AT lijieyang predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT feiliu predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT yaowu predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT qigenfang predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT xiaojunzhang predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT weidu predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT xuzhang predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT defengchen predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue AT ruihualuo predictivevalueofoccultmetastasisandsurvivalsignificanceofmetabolictumorvolumedeterminedbypetctinct12n0squamouscellcarcinomaofthetongue |