CXC chemokine ligand 12α-mediated increase in insulin secretion and survival of mouse pancreatic islets in response to oxidative stress through modulation of calcium uptake

CXC chemokine ligand 12α-mediated increase in insulin secretion and survival of mouse pancreatic islets in response to oxidative stress through modulation of calcium uptake

We examined whether CXCL12α improves insulin secretion by influencing the Ca2+ oscillation pattern and Ca2+ influx ([Ca2+]i), thereby enhancing the viability of pancreatic islet cells in oxidative stress. The islets of Langerhans were isolated from male OF1 mice and pretreated with 40 ng/mL of CXCL1...

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Bibliographic Details
Main Authors: Vidaković Melita, Caballero-Garrido Ernesto, Mihailović Mirjana, Arambašić-Jovanović Jelena, Sinadinović Marija, Rajić Jovana, Uskoković Aleksandra, Dinić Svetlana, Grdović Nevena, Đorđević Miloš, Tolić Anja, Poznanović Goran
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2018-01-01
Series:Archives of Biological Sciences
Subjects:
diabetes
calcium
CXC chemokine ligand 12α
insulin
pancreatic islet cells
voltage-gated calcium channels
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2018/0354-46641700040V.pdf

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