Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway

Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway

Indoxyl sulfate (IS), a uremic toxin derived from dietary tryptophan metabolism by the gut microbiota, is an endogenous aryl hydrocarbon receptor (AhR) agonist and a key player in bone remodeling. Resveratrol (RSV), an AhR antagonist, plays a protective role in shielding against AhR ligands. Our stu...

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Bibliographic Details
Main Authors:	Wen-Chih Liu, Jia-Fwu Shyu, Yuh-Feng Lin, Hui-Wen Chiu, Paik Seong Lim, Chien-Lin Lu, Cai-Mei Zheng, Yi-Chou Hou, Po-Han Chen, Kuo-Cheng Lu
Format:	Article
Language:	English
Published:	MDPI AG 2020-10-01
Series:	International Journal of Molecular Sciences
Subjects:	aryl hydrocarbon receptor indoxyl sulfate osteoblast chronic kidney disease Runx2 mitogen-activated protein kinase
Online Access:	https://www.mdpi.com/1422-0067/21/20/7483

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