Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein
(1) Background: Chronic kidney disease (CKD) affects more than 800 million global population. Early detection followed by clinical management is among the best approaches for the affected individuals. However, a sensitive screening tool is not yet available. (2) Methods: We retrospectively reviewed...
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/379 |
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| author | Ming-Feng Wu Ching-Hsiao Lee Po-Hsin Pai Jiunn-Min Wang |
| author_facet | Ming-Feng Wu Ching-Hsiao Lee Po-Hsin Pai Jiunn-Min Wang |
| author_sort | Ming-Feng Wu |
| collection | DOAJ |
| description | (1) Background: Chronic kidney disease (CKD) affects more than 800 million global population. Early detection followed by clinical management is among the best approaches for the affected individuals. However, a sensitive screening tool is not yet available. (2) Methods: We retrospectively reviewed 600 patients aged >20 years with a full range of estimated glomerular filtration rate (eGFR) for clinical assessment of kidney function between 1 January 2020, to 30 April 2021, at the Taichung Veterans General Hospital, Taichung, Taiwan. With stratified sampling based on the level of eGFR, participants were evenly grouped into training and validation sets for predictive modeling. Concurrent records of laboratory data from urine samples were used as inputs to the model. (3) Results: The predictive model proposed two formulae based on urine conductivity for detecting suspected early-stage CKD. One formula, P_male45, was for used male subjects aged ≥45 years, and it had a prediction accuracy of 76.3% and a sensitivity of 97.3%. The other formula, P_female55, was used for female subjects aged ≥55 years. It had a prediction accuracy of 81.9% and a sensitivity of 98.4%. Urine conductivity, however, had low associations with urine glucose and urine protein levels. (4) Conclusion: The two predictive models were low-cost and provided rapid detection. Compared to urine protein, these models had a better screening performance for suspected early-stage CKD. It may also be applied for monitoring CKD in patients with progressing diabetes mellitus. |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:39Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-1aa922eb86f14f658f8d694bc2f543a82023-11-16T19:17:22ZengMDPI AGBiomedicines2227-90592023-01-0111237910.3390/biomedicines11020379Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine ProteinMing-Feng Wu0Ching-Hsiao Lee1Po-Hsin Pai2Jiunn-Min Wang3Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Medical Technology of Medicine, Nursing and Management, Miaoli 350, TaiwanDepartment of Pathology & Laboratory Medicine, Taichung Veterans General Hospital, Taichung 407, TaiwanDepartment of Pathology & Laboratory Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan(1) Background: Chronic kidney disease (CKD) affects more than 800 million global population. Early detection followed by clinical management is among the best approaches for the affected individuals. However, a sensitive screening tool is not yet available. (2) Methods: We retrospectively reviewed 600 patients aged >20 years with a full range of estimated glomerular filtration rate (eGFR) for clinical assessment of kidney function between 1 January 2020, to 30 April 2021, at the Taichung Veterans General Hospital, Taichung, Taiwan. With stratified sampling based on the level of eGFR, participants were evenly grouped into training and validation sets for predictive modeling. Concurrent records of laboratory data from urine samples were used as inputs to the model. (3) Results: The predictive model proposed two formulae based on urine conductivity for detecting suspected early-stage CKD. One formula, P_male45, was for used male subjects aged ≥45 years, and it had a prediction accuracy of 76.3% and a sensitivity of 97.3%. The other formula, P_female55, was used for female subjects aged ≥55 years. It had a prediction accuracy of 81.9% and a sensitivity of 98.4%. Urine conductivity, however, had low associations with urine glucose and urine protein levels. (4) Conclusion: The two predictive models were low-cost and provided rapid detection. Compared to urine protein, these models had a better screening performance for suspected early-stage CKD. It may also be applied for monitoring CKD in patients with progressing diabetes mellitus.https://www.mdpi.com/2227-9059/11/2/379chronic kidney disease (CKD)estimated glomerular filtration rate (eGFR)urine conductivitysensitivityurine protein |
| spellingShingle | Ming-Feng Wu Ching-Hsiao Lee Po-Hsin Pai Jiunn-Min Wang Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein Biomedicines chronic kidney disease (CKD) estimated glomerular filtration rate (eGFR) urine conductivity sensitivity urine protein |
| title | Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein |
| title_full | Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein |
| title_fullStr | Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein |
| title_full_unstemmed | Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein |
| title_short | Screening Cases of Suspected Early Stage Chronic Kidney Disease from Clinical Laboratory Data: The Comparison between Urine Conductivity and Urine Protein |
| title_sort | screening cases of suspected early stage chronic kidney disease from clinical laboratory data the comparison between urine conductivity and urine protein |
| topic | chronic kidney disease (CKD) estimated glomerular filtration rate (eGFR) urine conductivity sensitivity urine protein |
| url | https://www.mdpi.com/2227-9059/11/2/379 |
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