Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder
We investigated whether the abnormal rhythms in infants are related to the future development of autism spectrum disorder (ASD), using a questionnaire from September to October 2016. The parents of 160 children with ASD (male, n = 123; female, n = 37) were recruited from two hospitals in K and H cit...
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MDPI AG
2024-03-01
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| Series: | Clocks & Sleep |
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| Online Access: | https://www.mdpi.com/2624-5175/6/1/12 |
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| author | Teruhisa Miike Kentaro Oniki Makiko Toyoura Shiro Tonooka Seiki Tajima Jun Kinoshita Junji Saruwatari Yukuo Konishi |
| author_facet | Teruhisa Miike Kentaro Oniki Makiko Toyoura Shiro Tonooka Seiki Tajima Jun Kinoshita Junji Saruwatari Yukuo Konishi |
| author_sort | Teruhisa Miike |
| collection | DOAJ |
| description | We investigated whether the abnormal rhythms in infants are related to the future development of autism spectrum disorder (ASD), using a questionnaire from September to October 2016. The parents of 160 children with ASD (male, n = 123; female, n = 37) were recruited from two hospitals in K and H cities, and as a control group, 145 children (male, n = 75; female, n = 70) were recruited from four nursery schools in T city. The associations between ASD and bedtime and waking time on weekdays and weekends in infancy (<1 years of age), at 1–3 years, and at 3–5 years of ages were studied using a multivariable logistic regression analysis. In particular, at <3 years of age, the following factors were associated with an increased prevalence of ASD in the future: (1) short sleep periods (<8 h); (2) taking a long time to fall asleep (>60 min); (3) sleep beginning after 22:00; (4) a wake-up time after 08:00; and (5) frequent (>3 times) and long-term awakening periods (>60 min). The misalignment and/or shift of the circadian rhythm in infants may be one of the precursors and/or risk factors for the future development of ASD. |
| first_indexed | 2024-04-24T18:25:19Z |
| format | Article |
| id | doaj.art-1aacc2f360224c5d90432d9f26e80925 |
| institution | Directory Open Access Journal |
| issn | 2624-5175 |
| language | English |
| last_indexed | 2024-04-24T18:25:19Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clocks & Sleep |
| spelling | doaj.art-1aacc2f360224c5d90432d9f26e809252024-03-27T13:31:43ZengMDPI AGClocks & Sleep2624-51752024-03-016117018210.3390/clockssleep6010012Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum DisorderTeruhisa Miike0Kentaro Oniki1Makiko Toyoura2Shiro Tonooka3Seiki Tajima4Jun Kinoshita5Junji Saruwatari6Yukuo Konishi7Hyogo Rehabilitation Central Hospital, Children’s Sleep and Development Medical Research Center, Kobe 651-2181, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, JapanHyogo Rehabilitation Central Hospital, Children’s Sleep and Development Medical Research Center, Kobe 651-2181, JapanKagoshima Comprehensive Clinic for Disabled Children, Kagoshima 891-0175, JapanHyogo Rehabilitation Central Hospital, Children’s Sleep and Development Medical Research Center, Kobe 651-2181, JapanJapanese Association of Baby Science Learners, Tokushima 770-0052, JapanDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, JapanCenter for Baby Science, Doshisha University, Kyoto 619-0225, JapanWe investigated whether the abnormal rhythms in infants are related to the future development of autism spectrum disorder (ASD), using a questionnaire from September to October 2016. The parents of 160 children with ASD (male, n = 123; female, n = 37) were recruited from two hospitals in K and H cities, and as a control group, 145 children (male, n = 75; female, n = 70) were recruited from four nursery schools in T city. The associations between ASD and bedtime and waking time on weekdays and weekends in infancy (<1 years of age), at 1–3 years, and at 3–5 years of ages were studied using a multivariable logistic regression analysis. In particular, at <3 years of age, the following factors were associated with an increased prevalence of ASD in the future: (1) short sleep periods (<8 h); (2) taking a long time to fall asleep (>60 min); (3) sleep beginning after 22:00; (4) a wake-up time after 08:00; and (5) frequent (>3 times) and long-term awakening periods (>60 min). The misalignment and/or shift of the circadian rhythm in infants may be one of the precursors and/or risk factors for the future development of ASD.https://www.mdpi.com/2624-5175/6/1/12ASDinfantscircadian rhythmsleep disordermelatonin‚ prophylactic therapy |
| spellingShingle | Teruhisa Miike Kentaro Oniki Makiko Toyoura Shiro Tonooka Seiki Tajima Jun Kinoshita Junji Saruwatari Yukuo Konishi Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder Clocks & Sleep ASD infants circadian rhythm sleep disorder melatonin‚ prophylactic therapy |
| title | Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder |
| title_full | Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder |
| title_fullStr | Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder |
| title_full_unstemmed | Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder |
| title_short | Disruption of Circadian Sleep/Wake Rhythms in Infants May Herald Future Development of Autism Spectrum Disorder |
| title_sort | disruption of circadian sleep wake rhythms in infants may herald future development of autism spectrum disorder |
| topic | ASD infants circadian rhythm sleep disorder melatonin‚ prophylactic therapy |
| url | https://www.mdpi.com/2624-5175/6/1/12 |
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