To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India
Background: Neonatal sepsis term is an infection of newborns <28 days of age. It is a common cause of death in developing countries. The receptor-gamma receptor FCGR2A has been shown to be associated with neonatal sepsis. It is an activating receptor found in many cell types such as monocytes, ne...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Indian Association of Pediatric Surgeons |
| Subjects: | |
| Online Access: | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=6;spage=718;epage=722;aulast=Chowdhary |
| _version_ | 1828166010813808640 |
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| author | Sarita Chowdhary Kanika Sharma Ashish Ashish Abhay Kumar Yadav Pranay Panigrahi Akas Mishra Deepak Kumar Royana Singh |
| author_facet | Sarita Chowdhary Kanika Sharma Ashish Ashish Abhay Kumar Yadav Pranay Panigrahi Akas Mishra Deepak Kumar Royana Singh |
| author_sort | Sarita Chowdhary |
| collection | DOAJ |
| description | Background: Neonatal sepsis term is an infection of newborns <28 days of age. It is a common cause of death in developing countries. The receptor-gamma receptor FCGR2A has been shown to be associated with neonatal sepsis. It is an activating receptor found in many cell types such as monocytes, neutrophils, macrophages, platelets, and others. The receptor has a polymorphism (single-nucleotide polymorphism rs1801274) in its gene (FCGR2A) that encodes either a histidine (H) or arginine (R) at amino acid position 131. There are many studies showing the impact of these FCGR2A polymorphisms on sepsis. Our study aims to determine the prevalence of Fc-gamma receptor FCGR2A (rs1801274) polymorphism in neonatal sepsis and control in Eastern UP populations.
Patients and Methods: We conducted a cross-sectional descriptive study of 590 patients (310 healthy individuals and 280 sepsis patients) to determine polymorphisms in the CD32A coding region in neonates. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene.
Discussion: In our study, the prevalence of FcγRIIa polymorphism is more in neonates with sepsis than in noninfected neonates. It was observed that the heterozygous allele (AG) were significantly increased in septic neonates when compared to the normal.
Conclusion: Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis. |
| first_indexed | 2024-04-12T01:54:31Z |
| format | Article |
| id | doaj.art-1aaf1a501f8d4279b7a1448ac7317065 |
| institution | Directory Open Access Journal |
| issn | 0971-9261 1998-3891 |
| language | English |
| last_indexed | 2024-04-12T01:54:31Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Association of Pediatric Surgeons |
| spelling | doaj.art-1aaf1a501f8d4279b7a1448ac73170652022-12-22T03:52:50ZengWolters Kluwer Medknow PublicationsJournal of Indian Association of Pediatric Surgeons0971-92611998-38912022-01-0127671872210.4103/jiaps.jiaps_52_22To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North IndiaSarita ChowdharyKanika SharmaAshish AshishAbhay Kumar YadavPranay PanigrahiAkas MishraDeepak KumarRoyana SinghBackground: Neonatal sepsis term is an infection of newborns <28 days of age. It is a common cause of death in developing countries. The receptor-gamma receptor FCGR2A has been shown to be associated with neonatal sepsis. It is an activating receptor found in many cell types such as monocytes, neutrophils, macrophages, platelets, and others. The receptor has a polymorphism (single-nucleotide polymorphism rs1801274) in its gene (FCGR2A) that encodes either a histidine (H) or arginine (R) at amino acid position 131. There are many studies showing the impact of these FCGR2A polymorphisms on sepsis. Our study aims to determine the prevalence of Fc-gamma receptor FCGR2A (rs1801274) polymorphism in neonatal sepsis and control in Eastern UP populations. Patients and Methods: We conducted a cross-sectional descriptive study of 590 patients (310 healthy individuals and 280 sepsis patients) to determine polymorphisms in the CD32A coding region in neonates. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene. Discussion: In our study, the prevalence of FcγRIIa polymorphism is more in neonates with sepsis than in noninfected neonates. It was observed that the heterozygous allele (AG) were significantly increased in septic neonates when compared to the normal. Conclusion: Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis.http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=6;spage=718;epage=722;aulast=Chowdharyneonatal sepsispolymorphismgenotypingsingle-nucleotide polymorphism |
| spellingShingle | Sarita Chowdhary Kanika Sharma Ashish Ashish Abhay Kumar Yadav Pranay Panigrahi Akas Mishra Deepak Kumar Royana Singh To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India Journal of Indian Association of Pediatric Surgeons neonatal sepsis polymorphism genotyping single-nucleotide polymorphism |
| title | To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India |
| title_full | To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India |
| title_fullStr | To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India |
| title_full_unstemmed | To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India |
| title_short | To determine the genotyping of Fc-gamma receptor FCGR2A polymorphism as genetic susceptibility to neonatal sepsis: A study from a tertiary center of North India |
| title_sort | to determine the genotyping of fc gamma receptor fcgr2a polymorphism as genetic susceptibility to neonatal sepsis a study from a tertiary center of north india |
| topic | neonatal sepsis polymorphism genotyping single-nucleotide polymorphism |
| url | http://www.jiaps.com/article.asp?issn=0971-9261;year=2022;volume=27;issue=6;spage=718;epage=722;aulast=Chowdhary |
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