In Silico Activity Prediction and Docking Studies of the Binding Mechanisms of Levofloxacin Structure Derivatives to Active Receptor Sites of Bacterial Type IIA Topoisomerases

In Silico Activity Prediction and Docking Studies of the Binding Mechanisms of Levofloxacin Structure Derivatives to Active Receptor Sites of Bacterial Type IIA Topoisomerases

The need for new antimicrobial agents (AntAg) is driven by the persistent antibiotic resistance in microorganisms, as well as the increasing frequency of pandemics. Due to the deficiency of AntAg, research aimed at developing speedy approaches to find new drug candidates is relevant. This study aims...

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Bibliographic Details
Main Authors: Elena V. Uspenskaya, Vasilisa A. Sukhanova, Ekaterina S. Kuzmina, Tatyana V. Pleteneva, Olga V. Levitskaya, Timur M. Garaev, Anton V. Syroeshkin
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Scientia Pharmaceutica
Subjects:
in silico methods
topological indices
Pa/Pi ratios
molecular docking
free energy of binding
type IIA topoisomerases targets
Online Access:https://www.mdpi.com/2218-0532/92/1/1

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