Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern
Antibiotic resistance among <i>Helicobacter pylori</i> strains is the major cause of eradication failure. Resistance prevalence is dynamic and can greatly vary among countries over the years. We revealed <i>H. pylori</i> resistance trends for five antibiotics in 14 countries...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/2/332 |
| _version_ | 1797622753308704768 |
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| author | Lyudmila Boyanova Petyo Hadzhiyski Raina Gergova Rumyana Markovska |
| author_facet | Lyudmila Boyanova Petyo Hadzhiyski Raina Gergova Rumyana Markovska |
| author_sort | Lyudmila Boyanova |
| collection | DOAJ |
| description | Antibiotic resistance among <i>Helicobacter pylori</i> strains is the major cause of eradication failure. Resistance prevalence is dynamic and can greatly vary among countries over the years. We revealed <i>H. pylori</i> resistance trends for five antibiotics in 14 countries through articles predominantly published in 2018–2022, since the latest data can best show the most recent trends in resistance evolution. Amoxicillin resistance generally exhibited no evolution, yet it increased in Bulgaria, Iran, China, and Vietnam. Metronidazole resistance exhibited different trends, including an increase, a decrease and no evolution in six, three, and five studies, respectively. Clarithromycin resistance increased in Australia, Belgium, Bulgaria, Italy, Iran, and Taiwan, but remained stable in France, Spain, Russia, China, Chile, and Colombia. Tetracycline resistance was low and stable except in Iran. Levofloxacin resistance increased in four European and six other countries/regions, without significant increases in France, Spain, and Chile. In Chile, triple resistance also increased. In countries such as France and Spain, resistance to most antibiotics was stabilized, while in Bulgaria, Belgium, Iran and Taiwan, resistance to three or more agents was reported. Use of non-recommended regimens, national antibiotic consumption, patient’s compliance, host factors, strain virulence, migrations, and azithromycin overuse during the COVID-19 pandemic can influence resistance evolution. New drugs, eradication regimens and diagnostic methods, such as next-generation sequencing can improve <i>H. pylori</i> infection control. |
| first_indexed | 2024-03-11T09:14:43Z |
| format | Article |
| id | doaj.art-1ab02389409d4c4f8340f02656885ffb |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:14:43Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1ab02389409d4c4f8340f02656885ffb2023-11-16T18:43:31ZengMDPI AGAntibiotics2079-63822023-02-0112233210.3390/antibiotics12020332Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing ConcernLyudmila Boyanova0Petyo Hadzhiyski1Raina Gergova2Rumyana Markovska3Department of Medical Microbiology, Medical Faculty, Medical University of Sofia, Zdrave str. 2, 1431 Sofia, BulgariaSpecialized Hospital for Active Pediatric Treatment, Medical University of Sofia, “Acad. Ivan Evstatiev Geshov” blvd., 1606 Sofia, BulgariaDepartment of Medical Microbiology, Medical Faculty, Medical University of Sofia, Zdrave str. 2, 1431 Sofia, BulgariaDepartment of Medical Microbiology, Medical Faculty, Medical University of Sofia, Zdrave str. 2, 1431 Sofia, BulgariaAntibiotic resistance among <i>Helicobacter pylori</i> strains is the major cause of eradication failure. Resistance prevalence is dynamic and can greatly vary among countries over the years. We revealed <i>H. pylori</i> resistance trends for five antibiotics in 14 countries through articles predominantly published in 2018–2022, since the latest data can best show the most recent trends in resistance evolution. Amoxicillin resistance generally exhibited no evolution, yet it increased in Bulgaria, Iran, China, and Vietnam. Metronidazole resistance exhibited different trends, including an increase, a decrease and no evolution in six, three, and five studies, respectively. Clarithromycin resistance increased in Australia, Belgium, Bulgaria, Italy, Iran, and Taiwan, but remained stable in France, Spain, Russia, China, Chile, and Colombia. Tetracycline resistance was low and stable except in Iran. Levofloxacin resistance increased in four European and six other countries/regions, without significant increases in France, Spain, and Chile. In Chile, triple resistance also increased. In countries such as France and Spain, resistance to most antibiotics was stabilized, while in Bulgaria, Belgium, Iran and Taiwan, resistance to three or more agents was reported. Use of non-recommended regimens, national antibiotic consumption, patient’s compliance, host factors, strain virulence, migrations, and azithromycin overuse during the COVID-19 pandemic can influence resistance evolution. New drugs, eradication regimens and diagnostic methods, such as next-generation sequencing can improve <i>H. pylori</i> infection control.https://www.mdpi.com/2079-6382/12/2/332<i>Helicobacter pylori</i>evolutionincreaseantibioticresistanceamoxicillin |
| spellingShingle | Lyudmila Boyanova Petyo Hadzhiyski Raina Gergova Rumyana Markovska Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern Antibiotics <i>Helicobacter pylori</i> evolution increase antibiotic resistance amoxicillin |
| title | Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern |
| title_full | Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern |
| title_fullStr | Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern |
| title_full_unstemmed | Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern |
| title_short | Evolution of <i>Helicobacter pylori</i> Resistance to Antibiotics: A Topic of Increasing Concern |
| title_sort | evolution of i helicobacter pylori i resistance to antibiotics a topic of increasing concern |
| topic | <i>Helicobacter pylori</i> evolution increase antibiotic resistance amoxicillin |
| url | https://www.mdpi.com/2079-6382/12/2/332 |
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