Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.

Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.

BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of ergocalciferol. This study describes the therapeutic...

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Main Authors: Richard G Moore, Thilo S Lange, Katina Robinson, Kyu K Kim, Alper Uzun, Timothy C Horan, Nada Kawar, Naohiro Yano, Sharon R Chu, Quanfu Mao, Laurent Brard, Monique E DePaepe, James F Padbury, Leggy A Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K Singh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3317945?pdf=render

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