Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis
Cancer stem cells (CSCs) are highly related to initiate metastasis and drive tumor relapse/propagation, and the induced cancer stemness and plasticity render cancer intractable to various therapeutic approaches. To address them, a CSC membrane‐based fusion strategy is presented to target and attenua...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-02-01
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| Series: | Small Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/smsc.202300111 |
| _version_ | 1797306779660451840 |
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| author | Xiulin Dong Qiaoling Yang Hai Wang Chunyan Zhu Taixia Wang Chao Fang Yan Zhang Jianjun Yang Kun Zhang Qing Zhao |
| author_facet | Xiulin Dong Qiaoling Yang Hai Wang Chunyan Zhu Taixia Wang Chao Fang Yan Zhang Jianjun Yang Kun Zhang Qing Zhao |
| author_sort | Xiulin Dong |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are highly related to initiate metastasis and drive tumor relapse/propagation, and the induced cancer stemness and plasticity render cancer intractable to various therapeutic approaches. To address them, a CSC membrane‐based fusion strategy is presented to target and attenuate cancer stemness and plasticity, and accordingly homogenous CSC‐inherited fusion membrane‐coated biomimetic nanoeffectors based on doxorubicin‐loaded hydroxyapatite nanoparticles are engineered. Such biomimetic nanoeffectors coated with fusion membrane consisting of CSCs and cancer cells can not only specifically target the solid breast tumor cells, but also target the latent CSCs. Systematic experiments validate that the constructed nanoeffectors disrupt energy metabolism, trigger lethal mitochondrial apoptosis, remarkably inhibit tumor proliferation, and downregulate the expressions of some target proteins associated with cancer stemness and metastasis to attenuate cancer stemness and the induced plasticity. Contributed by them, such nanoeffectors have been demonstrated to successfully hinder the progression of breast cancer, and decrease lung metastasis in two cancer metastasis mouse models. Such CSCs membrane‐based fusion membrane strategy provides a new candidate avenue rather than the currently dominant immune‐related pathway to repress cancer metastasis via targeting and attenuating cancer stemness. |
| first_indexed | 2024-03-08T00:46:45Z |
| format | Article |
| id | doaj.art-1ab2a734c5f94bf98cb6112c73f8428a |
| institution | Directory Open Access Journal |
| issn | 2688-4046 |
| language | English |
| last_indexed | 2024-03-08T00:46:45Z |
| publishDate | 2024-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj.art-1ab2a734c5f94bf98cb6112c73f8428a2024-02-15T05:52:51ZengWiley-VCHSmall Science2688-40462024-02-0142n/an/a10.1002/smsc.202300111Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer MetastasisXiulin Dong0Qiaoling Yang1Hai Wang2Chunyan Zhu3Taixia Wang4Chao Fang5Yan Zhang6Jianjun Yang7Kun Zhang8Qing Zhao9Department of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaDepartment of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University No. 301 Yan-chang-zhong Road Shanghai 200072 P. R. ChinaDepartment of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University No. 301 Yan-chang-zhong Road Shanghai 200072 P. R. ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaDepartment of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University No. 301 Yan-chang-zhong Road Shanghai 200072 P. R. ChinaDepartment of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University School of Medicine Tongji University No. 301 Yan-chang-zhong Road Shanghai 200072 P. R. ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaDepartment of Pharmacy and Central Laboratory Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu 610072 Sichuan P. R. ChinaCancer stem cells (CSCs) are highly related to initiate metastasis and drive tumor relapse/propagation, and the induced cancer stemness and plasticity render cancer intractable to various therapeutic approaches. To address them, a CSC membrane‐based fusion strategy is presented to target and attenuate cancer stemness and plasticity, and accordingly homogenous CSC‐inherited fusion membrane‐coated biomimetic nanoeffectors based on doxorubicin‐loaded hydroxyapatite nanoparticles are engineered. Such biomimetic nanoeffectors coated with fusion membrane consisting of CSCs and cancer cells can not only specifically target the solid breast tumor cells, but also target the latent CSCs. Systematic experiments validate that the constructed nanoeffectors disrupt energy metabolism, trigger lethal mitochondrial apoptosis, remarkably inhibit tumor proliferation, and downregulate the expressions of some target proteins associated with cancer stemness and metastasis to attenuate cancer stemness and the induced plasticity. Contributed by them, such nanoeffectors have been demonstrated to successfully hinder the progression of breast cancer, and decrease lung metastasis in two cancer metastasis mouse models. Such CSCs membrane‐based fusion membrane strategy provides a new candidate avenue rather than the currently dominant immune‐related pathway to repress cancer metastasis via targeting and attenuating cancer stemness.https://doi.org/10.1002/smsc.202300111cancer stem cellscancer stemness and plasticity attenuationenergy metabolism disruptionfusion membranestumor metastasis and recurrence |
| spellingShingle | Xiulin Dong Qiaoling Yang Hai Wang Chunyan Zhu Taixia Wang Chao Fang Yan Zhang Jianjun Yang Kun Zhang Qing Zhao Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis Small Science cancer stem cells cancer stemness and plasticity attenuation energy metabolism disruption fusion membranes tumor metastasis and recurrence |
| title | Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis |
| title_full | Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis |
| title_fullStr | Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis |
| title_full_unstemmed | Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis |
| title_short | Targetedly Attenuating Cancer Stemness and Plasticity by Homologous Cancer Stem Cell‐Inherited Fusion Membrane Nanoeffectors against Cancer Metastasis |
| title_sort | targetedly attenuating cancer stemness and plasticity by homologous cancer stem cell inherited fusion membrane nanoeffectors against cancer metastasis |
| topic | cancer stem cells cancer stemness and plasticity attenuation energy metabolism disruption fusion membranes tumor metastasis and recurrence |
| url | https://doi.org/10.1002/smsc.202300111 |
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