Musculoskeletal defects associated with myosin heavy chain‐embryonic loss of function are mediated by the YAP signaling pathway

Musculoskeletal defects associated with myosin heavy chain‐embryonic loss of function are mediated by the YAP signaling pathway

Abstract Mutations in MYH3, the gene encoding the developmental myosin heavy chain‐embryonic (MyHC‐embryonic) skeletal muscle‐specific contractile protein, cause several congenital contracture syndromes. Among these, recessive loss‐of‐function MYH3 mutations lead to spondylocarpotarsal synostosis (S...

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Bibliographic Details
Main Authors: Anushree Bharadwaj, Jaydeep Sharma, Jagriti Singh, Mahima Kumari, Tanushri Dargar, Bhargab Kalita, Sam J Mathew
Format: Article
Language:English
Published: Springer Nature 2023-09-01
Series:EMBO Molecular Medicine
Subjects:
Homeostasis
Mice
Myosin heavy chain‐embryonic
Skeletal muscle
YAP
Online Access:https://doi.org/10.15252/emmm.202217187

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