Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial
Abstract Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive paren...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | BMC Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12887-018-1201-0 |
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| author | R. Chingono H. Mebrahtu Z. Mupambireyi V. Simms H. A. Weiss P. Ndlovu F. Charasika M. Tomlinson L.D. Cluver F. M. Cowan L. Sherr |
| author_facet | R. Chingono H. Mebrahtu Z. Mupambireyi V. Simms H. A. Weiss P. Ndlovu F. Charasika M. Tomlinson L.D. Cluver F. M. Cowan L. Sherr |
| author_sort | R. Chingono |
| collection | DOAJ |
| description | Abstract Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. Methods The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0–24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. Discussion The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments. Trial registration This trial is registered with the Pan African Clinical Trials Registry (www.pactr.org), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered). |
| first_indexed | 2024-12-10T04:12:59Z |
| format | Article |
| id | doaj.art-1ab5b1e461914aa286c5f083bac2e175 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-10T04:12:59Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-1ab5b1e461914aa286c5f083bac2e1752022-12-22T02:02:40ZengBMCBMC Pediatrics1471-24312018-07-0118111010.1186/s12887-018-1201-0Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trialR. Chingono0H. Mebrahtu1Z. Mupambireyi2V. Simms3H. A. Weiss4P. Ndlovu5F. Charasika6M. Tomlinson7L.D. Cluver8F. M. Cowan9L. Sherr10Centre for Sexual Health HIV/AIDS Research (CeSHHAR)Department of Infection and Population Health, University College LondonCentre for Sexual Health HIV/AIDS Research (CeSHHAR)MRC Tropical Epidemiology Group, London School of Hygiene and Tropical MedicineMRC Tropical Epidemiology Group, London School of Hygiene and Tropical MedicineWorld Education Inc./Bantwana (WEI/B)World Education Inc./Bantwana (WEI/B)Department of Psychology, Stellenbosch UniversityUniversity of Cape TownCentre for Sexual Health HIV/AIDS Research (CeSHHAR)Department of Infection and Population Health, University College LondonAbstract Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents. Methods The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0–24 months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12 months after enrolment. A comprehensive process evaluation was conducted. Discussion The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments. Trial registration This trial is registered with the Pan African Clinical Trials Registry (www.pactr.org), registration number PACTR201701001387209; the trial was registered on 16th January 2017 (retrospectively registered).http://link.springer.com/article/10.1186/s12887-018-1201-0Early childhood stimulationInternal savings and lending schemeCase managementHIV exposed infantsZimbabwe |
| spellingShingle | R. Chingono H. Mebrahtu Z. Mupambireyi V. Simms H. A. Weiss P. Ndlovu F. Charasika M. Tomlinson L.D. Cluver F. M. Cowan L. Sherr Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial BMC Pediatrics Early childhood stimulation Internal savings and lending scheme Case management HIV exposed infants Zimbabwe |
| title | Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial |
| title_full | Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial |
| title_fullStr | Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial |
| title_full_unstemmed | Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial |
| title_short | Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial |
| title_sort | evaluating the effectiveness of a multi component intervention on early childhood development in paediatric hiv care and treatment programmes a randomised controlled trial |
| topic | Early childhood stimulation Internal savings and lending scheme Case management HIV exposed infants Zimbabwe |
| url | http://link.springer.com/article/10.1186/s12887-018-1201-0 |
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