Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node
Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294221001337 |
| _version_ | 1818974137397280768 |
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| author | Tzahi Neuman Alexander Maly Michael Alterman Aron Popovtzer Jeffrey M. Weinberger Nir Hirshoren |
| author_facet | Tzahi Neuman Alexander Maly Michael Alterman Aron Popovtzer Jeffrey M. Weinberger Nir Hirshoren |
| author_sort | Tzahi Neuman |
| collection | DOAJ |
| description | Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological investigation and multidisciplinary decision-making process of a heterotopic carcinoma ex pleomorphic adenoma arising in an intra-parotid lymph node. Materials and Methods: A literature search in the ''PubMed'' database using key words ''carcinoma ex pleomorphic adenoma'', ''parotid lymph node'', ''salivary gland'' and ''heterotopia'' was conducted. We describe the thorough pathological investigation and clinical decision-making process, focusing TNM staging system limitations. Results: A few case reports presented either normal appearing salivary tissue, benign tumors or low and high-grade salivary malignancies arising in lymph nodes. We present the investigation, controversies and treatment decision process of a 46-year-old man with CXPA in intra-parotid lymph node. Conclusions: The staging scheme does not distinguish between nodal spread and primary tumor arising in a lymph node. Multidisciplinary input regarding prognosis and follow-up plans, may consider heterotopia differently from the usual pattern of nodal spread. |
| first_indexed | 2024-12-20T15:35:17Z |
| format | Article |
| id | doaj.art-1ab5fc7e2c0e465babb5b9637f3156f8 |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-12-20T15:35:17Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-1ab5fc7e2c0e465babb5b9637f3156f82022-12-21T19:35:26ZengElsevierCancer Treatment and Research Communications2468-29422021-01-0128100435Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph nodeTzahi Neuman0Alexander Maly1Michael Alterman2Aron Popovtzer3Jeffrey M. Weinberger4Nir Hirshoren5Pathology department, IsraelPathology department, IsraelOral and Maxillofacial Surgery department, IsraelSharett Institute of Oncology, IsraelDepartment of Otolaryngology / Head & Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, IsraelDepartment of Otolaryngology / Head & Neck Surgery, Hadassah Hebrew-University Medical Center, Jerusalem, Israel; Address for correspondence: Nir Hirshoren, MD 0000-0002-5601-8336 Department of Otolaryngology/Head & Neck Surgery Hadassah Ein-Kerem, Jerusalem, 91120, Israel.Introduction: Heterotopia is the presence of a particular tissue / tumor at a non-physiological / ectopic site. The study primary goals: To review the current data investigating heterotopic, normal appearing, and diseased salivary gland tumors, in lymph nodes. To describe the meticulous pathological investigation and multidisciplinary decision-making process of a heterotopic carcinoma ex pleomorphic adenoma arising in an intra-parotid lymph node. Materials and Methods: A literature search in the ''PubMed'' database using key words ''carcinoma ex pleomorphic adenoma'', ''parotid lymph node'', ''salivary gland'' and ''heterotopia'' was conducted. We describe the thorough pathological investigation and clinical decision-making process, focusing TNM staging system limitations. Results: A few case reports presented either normal appearing salivary tissue, benign tumors or low and high-grade salivary malignancies arising in lymph nodes. We present the investigation, controversies and treatment decision process of a 46-year-old man with CXPA in intra-parotid lymph node. Conclusions: The staging scheme does not distinguish between nodal spread and primary tumor arising in a lymph node. Multidisciplinary input regarding prognosis and follow-up plans, may consider heterotopia differently from the usual pattern of nodal spread.http://www.sciencedirect.com/science/article/pii/S2468294221001337Carcinoma ex pleomorphic adenomaHeterotopiaIntra parotid lymph node parotidTNM staging system |
| spellingShingle | Tzahi Neuman Alexander Maly Michael Alterman Aron Popovtzer Jeffrey M. Weinberger Nir Hirshoren Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node Cancer Treatment and Research Communications Carcinoma ex pleomorphic adenoma Heterotopia Intra parotid lymph node parotid TNM staging system |
| title | Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node |
| title_full | Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node |
| title_fullStr | Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node |
| title_full_unstemmed | Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node |
| title_short | Salivary Gland Heterotopia, a Clinical and Pathological TNM Staging Challenge - Carcinoma ex Pleomorphic Adenoma Arising in a Parotid Lymph node |
| title_sort | salivary gland heterotopia a clinical and pathological tnm staging challenge carcinoma ex pleomorphic adenoma arising in a parotid lymph node |
| topic | Carcinoma ex pleomorphic adenoma Heterotopia Intra parotid lymph node parotid TNM staging system |
| url | http://www.sciencedirect.com/science/article/pii/S2468294221001337 |
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